血清淀粉样蛋白A水平与急性脑干梗死预后的相关性研究  

Correlation between serum amyloid A level and prognosis of acute brainstem infarction

作　　者：魏婉 桑红菲 张灏[1] 蒋敏海 WEI Wan;SANG Hongfei;ZHANG Hao;JIANG Minhai(Department of Neurology,Affiliated Hangzhou First People′s Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属杭州市第一人民医院神经内科,浙江杭州310000

出　　处：《中国现代医生》2021年第33期54-57,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2019RC234)。

摘　　要：目的探讨血清淀粉样蛋白A(SAA)水平与急性脑干梗死预后的相关性。方法选取2019年1月至2020年3月我院治疗的急性脑干梗死患者72例,测定其血清SAA水平。采用美国国立卫生研究院卒中量表(NIHSS)评分将入院时的患者分为轻度组和重度组;采用改良修订量表(mRS)评分将脑干梗死患者3个月预后分为预后良好与不良组,采用Logistic二元回归分析脑干梗死的独立危险因素。结果NIHSS>5分的患者组SAA水平显著高于NIHSS≤5的患者组,差异有统计学意义(P<0.05);在mRS>2的患者组的年龄,SAA水平显著高于mRS≤2组,差异有统计学意义(P<0.05)。结论年龄和SAA水平是急性脑干梗死预后的独立预后因素。SAA水平与脑干梗死的严重程度和预后密切相关,SAA水平是急性脑干梗死预后的独立危险因素。Objective To explore the correlation between serum amyloid A(SAA)level and prognosis of patients with acute brainstem infarction(ABI).Methods Seventy-two patients with ABI treated in our hospital from January 2019 to March 2020 were selected and their serum SAA levels were measured.The patients were divided into the mild group and the severe group based on National Institute Health Stroke Scale(NIHSS)score on the admission.The patients with brainstem infarction were divided into the good prognosis group and the bad prognosis group by modified revised scale(mRS)based on the 3-month prognosis,and the independent risk factors of brainstem infarction were analyzed by Logistic binary regression.Results The SAA level in patients with NIHSS>5 was significantly higher than that in patients with NIHSS≤5,with statistically significant difference(P<0.05).At the age of patients with mRS>2,SAA level was significantly higher than that of patients with mRS≤2,with statistically significant difference(P<0.05).Conclusion Age and SAA level are independent prognostic factors of ABI.SAA level is closely related to the severity and prognosis of brainstem infarction,and SAA level is an independent risk factor for the prognosis of ABI.

关 键 词：淀粉样蛋白A 急性脑干梗死 MRS评分 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]