小细胞肺癌经安罗替尼治疗后的特殊影像学评价  

Special imageologic evaluation of small cell lung cancer after treatment by anlotinib hydrochloride

作　　者：王宁军[1] 高业博 马银杰 薛鹏 高音[1] 周磊[1] 朱世杰[1] WANG Ningjun;GAO Yebo;MA Yinjie;XUE Peng;GAO Yin;ZHOU Lei;ZHU Shijie(Department of Oncology,Wangjing Hospital of China Academy of Chinese Medical Science,Beijing 100102,China)

机构地区：[1]中国中医科学院望京医院肿瘤科,北京100102

出　　处：《重庆医学》2022年第1期41-44,49,共5页Chongqing medicine

基　　金：国家自然科学基金面上项目(81573915)。

摘　　要：目的观察小细胞肺癌接受盐酸安罗替尼治疗后的影像学特殊变化并探讨其发生机制。方法选取2018年6月至2020年9月该院肿瘤科住院治疗的广泛期小细胞肺癌患者36例,在一线治疗进展后接受盐酸安罗替尼进行二线治疗。观察接受盐酸安罗替尼二线治疗后的疗效,以及肺部肿瘤在大小、形态及瘤体内部密度的变化情况。结果36例患者接受盐酸安罗替尼二线治疗后部分缓解10例,疾病稳定11例。部分缓解患者中肿瘤缩小6例,瘤体内部出现空洞4例;疾病稳定患者肺部肿瘤内部CT值较治疗前明显降低,差异有统计学意义(P<0.05)。结论空洞形成是服用安罗替尼治疗后的特殊影像学改变。Objective To observe the imageologic special changes of small cell lung cancer(SCLC)after treatment by anlotinib hydrochloride,and to explore its pathogenesis.Methods Thirty-six inpatients with extensive stage SCLC in the oncology department of this hospital from June 2018 to September 2020 were selected and conducted the second-line treatment by anlotinib hydrochloride after progress by the first-line treatment.The efficacy of second-line treatment by anlotinib hydrochloride was observed and the changes in the size,shape and interior density of tumor lump were also observed.Results After the second-line treatment of anlotinib hydrochloride,10 cases had the partial response(PR)and 11 cases had the stable disease(SD).Among partial patients with PR,6 cases had tumor shrinkage and 4 cases appeared the cavity inside the tumor.In the patients with stable stage,the CT values inside the lung tumors were significantly decreased compared with those before treatment,and the difference statistically significant(P<0.05).Conclusion The cavity formation is a special imageologic change after anlotinib treatment.

关 键 词：小细胞肺癌 盐酸安罗替尼 影像 

分 类 号：R734.2[医药卫生—肿瘤]