PD-1/PD-L1、TIM-3表达与食管癌临床病理特征及预后的关系  

Relationship between PD-1/PD-L1 and TIM-3 expressions with clinicopathological characteristics and prognosis of esophageal cancer

作　　者：刘凯[1] 刘燕[2] 黄莉[1] 刘凯 LIU Kai;LIU Yan;HUANG Li;LIU Kai(Department of Head and Neck Comprehensive Radiotherapy,Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830011,China;Department of Thoracic and Abdominal Radiotherapy,Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院头颈综合放射治疗科,乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院胸腹放射治疗科,乌鲁木齐830011

出　　处：《重庆医学》2022年第1期65-69,共5页Chongqing medicine

基　　金：新疆维吾尔自治区自然科学基金项目(2017D01C389)。

摘　　要：目的探讨PD-1/PD-L1、TIM-3表达与食管癌临床病理特征及预后的关系。方法收集2008年1月1日至2012年12月31日该院收治的行根治性手术治疗的104例食管癌患者术后病理标本,采用免疫组织化学法检测PD-1、PD-L1、TIM-3表达,对比癌组织、癌旁组织相关蛋白表达情况,分析其与临床病理特征的关系,并采用Kaplan-Meier与Cox回归模型分析相关因素与无进展生存期(PFS)的关系。结果与癌旁组织比较,癌组织PD-1、PD-L1、TIM-3阳性表达例数均明显升高,差异均有统计学意义(P<0.05)。PD-1、PD-L1、TIM-3表达与性别、年龄、族别、吸烟史、饮酒史无关,病理TNM分期越高癌组织三者表达水平越高,且PD-1表达水平可能与病变部位有关,肿瘤浸润程度越深、伴淋巴结转移者PD-L1、TIM-3表达水平越高,TIM-3可能与肿瘤分化程度有关。随访至2014年12月31日,PD-1、TIM-3对患者中位PFS有影响,PD-L1对患者中位PFS无影响,PD-1、TIM-3高表达可能是患者不良预后的独立影响因素。结论癌组织PD-1、TIM-3表达可能影响患者预后。Objective To investigate the relatioship between PD-1/PD-L1 and TIM-3 expressions with clinicopathological characteristics and prognosis of esophageal cancer.Methods The postoperative pathological samples in 104 patients with esophageal cancer radical surgery in this hospital from January 1,2008 to December 31,2012 were collected.The PD-1 and PD expressions were detected by immunohistochemistry.The related protein expressions were compared between the cancer tissues and paracancerous tissues.Their correlation with the clinicopathologic characteristics was analyzed.The Kaplan-Meier and Cox regression model were adopted to analyze the relationship between the related factors and progress free survival(PFS).Results Compared with paracancerous tissues,the number of cases of PD-1,PD-L1 and TIM-3 positive expression in cancer tissue were significantly increased,and the difference was statistically significant(P<0.05).The PD-1,PD-L1 and TIM-3 expressions had no relation with the gender,age,nationality,smoking history and drinking history.The higher the pathological TNM stage,the higher the expression level of the three in the cancer tissue,moreover the PD-1 expression level could be related to the location of the lesion.The deeper the tumor infiltration,the higher the PD-L1 and TIM-3 expression levels in the patients with lymph node metastasis,TIM-3 could be related to the degree of tumor differentiation.The follow-up lasted until December 31,2014.PD-1 and TIM-3 had the influence on the patient′s median PFS,moreover the high PD-L1 and TIM-3 expression could be the independent influencing factors of poor prognosis in the patients with esophageal cancer.Conclusion The PD-1 and TIM-3 expressions in cancer tissue may affect the prognosis of the patients.

关 键 词：食管肿瘤 PD-1/PD-L1 TIM-3 预后 

分 类 号：R735.1[医药卫生—肿瘤]