恩替卡韦联合氧化苦参碱治疗对肝纤维化患者肝功能及肝纤维化指标的影响  

The therapeutic value of entecavir combined with oxymatrine in the treatment of liver fibrosis and its effect on the expression of cytokines

作　　者：王光娜 王光玉 张少华[3] 黄晓锋 齐建立[4] WANG Guang-na;WANG Guang-yu;ZHANG Shao-hua(Department of hepatobiliary surgery,the Seventh People's Hospital of Hebei Province,(Hebei,Dingzhou,073000),China;Static distribution center,the Seventh People's Hospital of Hebei Province,(Hebei,Dingzhou,073000),China;Department of internal medicine,the Seventh People's Hospital of Hebei Province of Hebei geriatric hospital,(Hebei,Dingzhou,073000),China)

机构地区：[1]河北省第七人民医院肝胆外科,河北定州073000 [2]河北省第七人民医院静配中心 [3]河北省老年病医院普内科 [4]河北省第七人民医院消化内科

出　　处：《中西医结合肝病杂志》2022年第1期28-30,34,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：河北省2020年度医学科学研究课题计划(No.20200707)。

摘　　要：目的:探讨恩替卡韦联合氧化苦参碱治疗对肝纤维化患者肝功能及肝纤维化指标的影响。方法:选取2018年1月至2019年12月在我院消化科住院的慢性乙型肝炎肝纤维化患者98例,分为联合治疗组和恩替卡韦组各49例,两组患者均进行常规治疗,恩替卡韦组患者口服恩替卡韦治疗,联合治疗组患者采用恩替卡韦联合氧化苦参碱治疗,观察两组患者治疗前后肝功能、肝纤维化、炎症指标的变化及不良反应发生情况。结果:与恩替卡韦组相比,联合治疗组患者肝功能、肝纤维化、炎症指标好转时间、IL-6、IL-8、IL-10、TGF-β1、IFN-γ、TNF-α、肝功能指标、肝纤维化指标水平明显降低(P<0.05);与恩替卡韦组相比,联合治疗组IL-2水平明显下降(P<0.05),治疗总有效率较高(P<0.05);两组患者不良反应发生情况无明显差异(P>0.05)。结论:应用恩替卡韦联合氧化苦参碱治疗肝纤维化患者,可有效改善肝功能及肝纤维化程度,效果显著。Objective:To explore the therapeutic value of entecavir combined with oxymatrine in patients with liver fibrosis and the effect on the expression of cytokines.Methods:From January 2018 to December 2019,98 patients with liver fibrosis in the Department of Gastroenterology of our hospital were selected.The patients were divided into the combined treatment group and entecavir group with 49 cases in each group.Both groups were given routine treatment.Entecavir group was treated with entecavir.The combined treatment group was treated with entecavir combined with oxymatrine.The improvement time of liver function,liver fibrosis and inflammation indexes were observed.The levels of IL-6,IL-8,IL-2,IL-10,TGF-β1,IFN-γand TNF-αwere detected by ELISA.Total bilirubin(TBIL),aspartate aminotransferase(ASL),alanine aminotransferase(ALT),albumin/globulin(ALB/GLB)were detected by automatic biochemical analyzer.Procollagen typeⅢ(PCⅢ),collagen typeⅣ(Ⅳ-C),hyaluronic acid(HA)and laminin(LN)were detected by radioimmunoassay.Statistical treatment effect and adverse reactions were observed.Results:Compared with entecavir group,the improvement time of liver function,liver fibrosis,inflammatory indexes,IL-6,IL-8,IL-10,TGF-β1,IFN-γ,TNF-α,liver function indexes and liver fibrosis indexes in the combined treatment group were significantly lower than those in the entecavir group(P<0.05).Compared with entecavir group,the level of IL-2 in combined treatment group was significantly decreased(P<0.05).Compared with entecavir group,the total effective rate of combined treatment group was higher(P<0.05).Compared with entecavir group,the total adverse reactions of combined treatment group were higher(P>0.05).Conclusion:Entecavir and Oxymatrine can effectively reduce the levels of IL-6,IL-8,and IL-10,and improve liver function and degree of liver fibrosis.

关 键 词：肝纤维化 恩替卡韦 氧化苦参碱 细胞因子 

分 类 号：R575.2[医药卫生—消化系统]