锐孔-凝固浴法制备虫白蜡源高级烷醇微囊  

Preparation of Policosanol Microcapsules from Insect Wax by Sharp Pore-Coagulation Bath

作　　者：刘晓丽 罗秀梅 张锦砚 杜绍辉 刘佳佳 孙昂 马金菊[2] LIU Xiaoli;LUO Xiumei;ZHANG Jinyan;DU Shaohui;LIU Jiajia;SUN Ang;MA Jinju(Oxbridge College,Kunming University of Science and Technology,Yunnan Kunming 650106;Research Institute of Resources Insects,Chinese Academy of Forestry,Yunnan Kunming 650233)

机构地区：[1]昆明理工大学津桥学院,云南昆明650106 [2]中国林业科学研究院资源昆虫研究所,云南昆明650224

出　　处：《生物化工》2021年第6期95-98,共4页Biological Chemical Engineering

基　　金：国家级创新创业训练计划项目(201913329008)。

摘　　要：以海藻酸钠为囊材,研究不同实验参数对锐孔-凝固浴法制备虫白蜡源高级烷醇微囊成球效果及包封率的影响。确定最佳工艺条件:CaCl_(2)溶液浓度6%,固化液温度70℃,搅拌速度200 r/min,针头孔径0.49 mm,下滴高度2 cm,虫白蜡源高级烷醇添加量0.10 g。制备的微囊球形较圆,包封率75.50%,颗粒大小均匀,干燥前D90粒径为120~140μm,干燥后D90粒径为50~70μm。The effects of different experimental parameters on the morphology and encapsulation efficiency of the policosanol microcapsules prepared by a sharp pot-coagulation bath method with sodium alginate as capsule material are studied.The optimum conditions are determined as follows:concentration of CaCl_(2)solution is 6%,temperature of curing solution is 70℃,stirring speed is 200 r/min,needle aperture is 0.49 mm,drop height is 2 cm,adding amount of policosanol from insect wax was 0.10 g.The prepared microcapsules are spherical,the encapsulation efficiency is 75.50%,and the particle size of D90 is 120~140μm before drying,and 50~70μm after drying.

关 键 词：虫白蜡源高级烷醇 微胶囊 锐孔-凝固浴法 工艺 

分 类 号：R944.5[医药卫生—药剂学] TS202.3[医药卫生—药学]