急性胰腺炎患者血清脂肪酶、血清淀粉样蛋白A、转铁蛋白水平变化及其与病情严重程度的相关性  

Changes of serum lipase, serum amyloid A, and transferrin levels in patients with acute pancreatitis and their correlation with the severity of the disease

作　　者：刘见欢 陈婉婵 尹爱平 蒲荣 梁逸仙 LIU Jianhuan;CHEN Wanchan;YIN Aiping;Pu Rong;LIANG Yixian(Department of Laboratory Medicine,Dongguan Songshan Lake Central Hospital,Guangdong Province,Dongguan523326,China)

机构地区：[1]广东省东莞市松山湖中心医院检验科,广东东莞523326

出　　处：《中国当代医药》2022年第2期130-132,136,共4页China Modern Medicine

基　　金：广东省东莞市科技计划项目(2018507150241501)。

摘　　要：目的研究急性胰腺炎患者血清脂肪酶、血清淀粉样蛋白A、转铁蛋白水平变化及其与病情严重程度的相关性。方法选取2020年1月至2021年2月东莞市松山湖中心医院收治的80例急性胰腺炎患者作为观察组,根据急性胰腺炎轻重度将观察组分为轻症急性胰腺炎(MAP)组(47例)和重度急性胰腺炎(SAP)组(33例),选择同期92例体检健康者作为对照组。比较三组的血清脂肪酶、血清淀粉样蛋白A、转铁蛋白水平,并分析血清脂肪酶、血清淀粉样蛋白A、转铁蛋白水平与病情严重程度的相关性。结果SAP组血清脂肪酶、血清淀粉样蛋白A均高于MAP组、对照组,转铁蛋白低于MAP组、对照组,差异有统计学意义(P<0.05);MAP组血清脂肪酶、血清淀粉样蛋白A高于对照组,转铁蛋白低于对照组,差异有统计学意义(P<0.05)。急性胰腺炎患者血清脂肪酶、血清淀粉样蛋白A与病情严重程度呈正相关,转铁蛋白水平与病情严重程度呈负相关(P<0.05)。结论SAP患者血清脂肪酶、血清淀粉样蛋白A水平较高,转铁蛋白水平较低,血清脂肪酶、血清淀粉样蛋白A、转铁蛋白水平变化与病情程度有关,在急性胰腺炎的诊断中发挥着重要作用,对于临床具有较高参考价值。Objective To study the changes in serum lipase,serum amyloid A,and transferrin levels in patients with acute pancreatitis and their correlation with the severity of the disease.Methods A total of 80 patients with acute pancreatitis admitted to Dongguan Songshan Lake Central Hospital from January 2020 to February 2021 were selected as the observation group.According to the severity of acute pancreatitis,the observation group was divided into mild acute pancreatitis(MAP)group(47cases)and severe acute pancreatitis(SAP)group(33 cases),a total of 92 healthy people with physical examination during the same period were selected as the control group.The serum lipase,serum amyloid A,and transferrin levels of the three groups were compared,and the correlation between the serum lipase,serum amyloid A,and transferrin levels with the severity of the disease were analyzed.Results Serum lipase and serum amyloid A in SAP group were higher than those in MAP group and control group,and transferrin was lower than that in the MAP group and control group,the differences were statistically significant(P<0.05).Serum lipase and amyloid A starch in MAP group were higher than those of the control group,and transferrin was lower than that in the control group,the differences were statistically significant(P<0.05).Serum lipase and serum amyloid A in patients with acute pancreatitis were positively correlated with the severity of the disease,and the level of transferrin was negatively correlated with the severity of the disease(P<0.05).Conclusion The levels of serum lipase,serum amyloid A and transferrin are higher in patients with SAP.The changes in serum lipase,serum amyloid A and transferrin levels are related to the severity of the disease and play a role in the diagnosis of acute pancreatitis It plays an important role and has high reference value for clinical practice.

关 键 词：急性胰腺炎 血清脂肪酶 血清淀粉样蛋白A 转铁蛋白 

分 类 号：R576[医药卫生—消化系统]