金属有机框架作为模拟酶在生化分析中的应用进展  

Application of Metal-Organic Frameworks as Mimic Enzymes in Biochemical Analysis

作　　者：关桦楠[1] 张悦 王丹丹[1] 吴永存 彭勃 GUAN Huanan;ZHANG Yue;WANG Dandan;WU Yongcun;PENG Bo(College of Food Engineering,Harbin University of Commerce,Harbin 150028,China)

机构地区：[1]哈尔滨商业大学食品工程学院,黑龙江哈尔滨150028

出　　处：《食品工业科技》2022年第3期422-429,共8页Science and Technology of Food Industry

基　　金：国家自然科学基金面上项目(31370649);国家自然科学基金青年科学基金项目(31201376);黑龙江省自然科学基金(C2016034);哈尔滨商业大学“青年创新人才”支持计划(2019CX05);黑龙江省博士后科研启动项目(LBH-Q19027);黑龙江省领军人才支持计划(2020376);哈尔滨商业大学研究生科研创新项目(HSD20210705)。

摘　　要：相较于天然酶易失活和制备回收成本高等缺点,金属有机框架作为模拟酶具有制备简便、低成本和高稳定性等优点,已被广泛应用于众多领域中。该文简要地对金属有机框架进行了概述,讲述了金属有机框架的构成及其现有的种类,重点介绍了近年来金属有机框架作为模拟酶在葡萄糖、活性蛋白、脂类活性成分、维生素、无机盐、致病菌、重金属和其他活性物质等生化分析中的检测机理以及研究进展,并对该模拟酶的未来发展方向和应用前景进行了展望。Metal-organic frameworks as mimic enzymes have been widely used in many fields due to their advantages such as easy preparation,low cost,and high stability,compared with the shortcomings of natural enzymes such as easy inactivation and high cost of preparation and recovery.The outline of the metal-organic frameworks are briefly summarized and the composition of the metal-organic frameworks and their existing types are described.The detection mechanism and latest research progress of metal-organic frameworks as mimetic enzymes in the biochemical analysis of glucose,active protein,lipid active ingredients,vitamins,inorganic salts,pathogenic bacteria,heavy metals and other active substances are mainly introduced.The future challenges and application prospects of this mimetic enzymes are prospected.

关 键 词：金属有机框架 模拟酶 生化分析 催化 过氧化物酶 纳米材料 

分 类 号：Q599[生物学—生物化学]