长链非编码RNAs在肿瘤细胞死亡中的作用  

Role of long noncoding RNAs in tumor cell death

作　　者：李铮铮 刘雪锋 LI ZhengZheng;LIU XueFeng(Institute of Cancer Stem Cell,Dalian Medical University,Dalian 116044,China)

机构地区：[1]大连医科大学肿瘤干细胞研究院,大连116044

出　　处：《中国科学：生命科学》2021年第12期1701-1709,共9页Scientia Sinica(Vitae)

摘　　要：恶性肿瘤是严重威胁人类生命健康的一种疾病.如何有效杀死肿瘤细胞,延长患者生存时间,是全世界一直试图攻克的难题.细胞死亡通常分为由基因调控的程序性死亡,包括凋亡、焦亡、自噬性死亡、铁死亡和坏死性凋亡,以及由外部刺激引起的非程序性死亡,即坏死.长链非编码RNAs(long noncoding RNAs, lncRNAs)作为人类基因组的主要组成部分,在调控肿瘤细胞死亡进程中发挥重要的作用.本文概述了lncRNAs在肿瘤细胞各种死亡模式,特别是程序性死亡中的作用和分子机制,期望为肿瘤靶向治疗提供新的思路和方向.Malignant tumor is one of the most harmful human diseases. Thus, elucidating the mechanisms to efficiently kill tumor cells and elongating the survival time of patients have become pertinent. Cell death can be categorized as genetically regulated programmed cell death(PCD)(apoptosis, pyroptosis, autophagic cell death, ferroptosis, and necroptosis) and non-programmed cell death(necrosis,induced by external stimulation). As the major part of the human genome, long noncoding RNAs(lnc RNAs) play an important role in regulating tumor cell death. Thus, this review summarizes the role and mechanism of lnc RNAs in different types of tumor cell death,especially PCD, which will provide new ideas and directions for tumor-targeted therapy.

关 键 词：长链非编码RNAs 凋亡 焦亡 自噬性死亡 铁死亡 坏死性凋亡 

分 类 号：R730.2[医药卫生—肿瘤]