康复新液联合卡介菌多糖核酸治疗糜烂型口腔扁平苔藓临床研究  

Clinical Study on Kangfuxin Solution Combined with BCG Polysaccharide and Nucleic Acid Injection for Erosive Oral Lichen Planus

作　　者：吴叶 林孟勇 叶宸宇 WU Ye;LIN Mengyong;YE Chenyu

机构地区：[1]景宁畲族自治县人民医院口腔科,浙江景宁323500

出　　处：《新中医》2021年第23期141-144,共4页New Chinese Medicine

摘　　要：目的:观察康复新液联合卡介菌多糖核酸治疗糜烂型口腔扁平苔藓的临床疗效及对患者免疫功能的影响。方法:将72例糜烂型口腔扁平苔藓患者按随机数字表法分为对照组和观察组各36例。对照组给予卡介菌多糖核酸注射液治疗,观察组在对照组基础上联合康复新液治疗。观察2组治疗前后唾液中相关炎症因子[白蛋白(Alb)、白细胞介素-10(IL-10)、干扰素-γ(IFN-γ)]、血清中免疫球蛋白[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]水平变化,并评价2组的临床疗效和不良反应情况。结果:观察组总有效率为94.44%,高于对照组77.78%,差异有统计学意义(P<0.05)。治疗前,2组唾液中Alb、IFN-γ、IL-10水平比较,差异无统计学意义(P>0.05)。治疗后,2组唾液中Alb、IL-10水平较治疗前降低,IFN-γ水平较治疗前升高;且观察组唾液中Alb、IL-10水平低于对照组,IFN-γ水平高于对照组;差异均有统计学意义(P<0.05)。治疗前,2组免疫球蛋白水平比较,差异无统计学意义(P>0.05)。治疗后,2组IgA、IgG、IgM水平高于治疗前,观察组IgA、IgG、IgM水平均高于对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(χ^(2)=0.158,P=0.691)。结论:康复新液联合卡介菌多糖核酸治疗糜烂型口腔扁平苔藓患者疗效显著,能有效调节患者唾液中相关炎症因子水平,提高机体免疫力,不良反应少。Objective:To observe the clinical effect of the therapy of Kangfuxin solution combined with BCG polysaccharide and nucleic acid injection on the treatment of erosive oral lichen planus and its effect on immune function.Methods:A total of 72 erosive oral lichen planus patients were divided into the control group and the observation group by random number table,36 cases in each group.The control group was treated with BCG polysaccharide and nucleic acid injection,and the observation group was additionally treated with Kangfuxin solution based on the treatment of the control group.The changes in the levels of relevant inflammatory factors in saliva including albumin(Alb),interleukin-10(IL-10)and interferon-γ(IFN-γ),immunoglobulins in serum including immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)were observed before and after treatment.The clinical effect and adverse reactions in the two groups were evaluated.Results:The total effective rate was 94.44%in the observation group,significantly higher than that of 77.78%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference in the levels of Alb,IFN-γand IL-10 in saliva between the two groups(P>0.05).After treatment,the levels of Alb and IL-10 in saliva in both groups were decreased when compared with those before treatment,and the levels of IFN-γwere increased;the levels of Alb and IL-10 in saliva in the observation group were lower than those in the control group,and the level of IFN-γwas higher;differences were significant(P<0.05).Before treatment,there was no significant difference in the immunoglobulin levels between the two groups(P>0.05).After treatment,the levels of IgA,IgG and IgM in the two groups were higher than those before treatment,and the above levels in the observation group were higher than those in the control group,differences being significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(χ^(2)=0.158,P=0.691

关 键 词：口腔扁平苔藓 糜烂型 康复新液 卡介菌多糖核酸注射液 体液免疫 炎症因子 不良反应 

分 类 号：R781.5[医药卫生—口腔医学]