健脾降逆汤联合常规西药对宫颈癌化疗后不良反应的影响  

Effect of Jianpi Jiangni Tang Combined with Conventional Western Medicine on Adverse Reactions After Chemotherapy for Cervical Cancer

作　　者：赵明燕 ZHAO Mingyan

机构地区：[1]驻马店市中心医院肿瘤内科,河南驻马店463000

出　　处：《新中医》2021年第23期145-148,共4页New Chinese Medicine

摘　　要：目的:观察健脾降逆汤联合常规西药对宫颈癌化疗后不良反应的影响。方法:选取112例进行化疗的宫颈癌患者,按随机数字表法分为对照组及观察组各56例,对照组应用常规西药治疗,观察组在常规西药治疗基础上联合健脾降逆汤治疗,观察2组临床疗效,比较2组治疗前后中医证候积分、血常规(白细胞、红细胞、血红蛋白、血小板)、生活质量(QOL)评分变化,比较2组治疗后胃肠道不良反应情况。结果:观察组临床疗效总有效率为96.43%,高于对照组83.93%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分均较治疗前下降,观察组中医证候积分低于对照组,差异有统计学意义(P<0.05)。治疗后,2组白细胞、红细胞、血红蛋白、血小板水平及QOL评分均较治疗前上升,观察组上述5项指标值均高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组消化道不良反应总发生率为7.14%,对照组不良反应总发生率为21.43%,2组比较,差异有统计学意义(P<0.05)。结论:健脾降逆汤联合常规西药有助于缓解宫颈癌化疗后的临床症状,降低骨髓抑制、消化道等不良反应发生率,提高生活质量。Objective:To observe the effect of Jianpi Jiangni tang combined with conventional western medicine on adverse reactions after chemotherapy for cervical cancer.Methods:A total of 112 patients with cervical cancer who had undergone chemotherapy were selected and divided into the control group and the observation group according to random number table method,with 56 cases in each group.The control group was treated with conventional western medicine,and the observation group was additionally treated with Jianpi Jiangni tang based on the conventional treatment.The clinical effect in the two groups was observed;the changes of Chinese medicine syndrome score,blood routine including white blood cell,red blood cell,hemoglobin,platelet,and the score of Quality of Life(QOL)in the two groups before and after treatment,as well as the gastrointestinal adverse reactions were compared after treatment.Results:The total effective rate was 96.43%in the observation group,higher than that of 83.93%in the control group,the difference being significant(P<0.05).After treatment,the Chinese medicine syndrome scores in both groups were decreased when compared with those before treatment,and the score in the observation group was lower than that in the control group,the difference being significant(P<0.05).After treatment,the levels of white blood cell,red blood cell,hemoglobin,platelet and QOL scores in the two groups were increased when compared with those before treatment,and the levels of the above five indexes in the observation group were higher than those in the control group,differences being significant(P<0.05).After treatment,the total incidence of gastrointestinal adverse reactions was 7.14%in the observation group and 21.43%in the control group,the difference being significant(P<0.05).Conclusion:Jianpi Jiangni tang combined with conventional western medicine can improve the clinical symptoms of patients who had undergone chemotherapy for cervical cancer,reduce the incidence of adverse reactions such as bone marrow suppression a

关 键 词：宫颈癌 化疗 不良反应 健脾降逆汤 血常规 中医证候积分 

分 类 号：R737.33[医药卫生—肿瘤]