幽门螺杆菌与系统性炎症指标的相关性分析  

Association between Helicobacter pylori infection and Neutrophil and lymphocyte ratio in adult health checkup population in China

作　　者：宋琼 洪海燕[1] 万政策 高文[1] SONG Qiong;HONG Hai-yan;WAN Zheng-ce;GAO Wen(Physical Examination Center,Tongii Hospital,Tongji Medical College,Huazhong University of Science and Technology,430030 Wuhan,China)

机构地区：[1]华中科技大学同济医学院附属同济医院体检中心,湖北武汉430030

出　　处：《临床消化病杂志》2021年第6期398-402,共5页Chinese Journal of Clinical Gastroenterology

摘　　要：[目的]探讨成年体检人群幽门螺杆菌(Helicobacter pylori,Hp)感染与系统性炎症指标的相关性,以期为临床抗Hp治疗的必要性提供依据。[方法]采用横断面研究方法,收集进行过^(13)C呼气试验的成人健康体检者的人口学信息、体格测量指标、血生化指标、疾病史等特征,采用多元线性回归分析以探讨Hp感染与系统性炎症指标的关系。[结果]共纳入研究对象47261例,其中男29137例,女18124例;年龄(43.2±11.9)岁;Hp感染阳性率为27.2%。与Hp阴性者相比,Hp阳性者的白细胞计数、中性粒细胞计数、淋巴细胞计数及中性粒细胞/淋巴细胞比值均较高,而血小板/淋巴细胞比值较低;在调整了年龄、性别、BMI、高血压、糖尿病,高尿酸血症、血脂异常后,Hp感染者与白细胞计数呈正相关,与血小板/淋巴细胞比值呈负相关,差异有统计学意义(均P<0.05)。此外,Hp感染均与白细胞计数成正比,与血小板/淋巴细胞比值成反比;BMI与Hp感染对中性粒细胞/淋巴细胞比值的影响存在交互作用(P=0.050),在BMI<24的研究对象中,Hp感染阳性者的中性粒细胞/淋巴细胞比值高于Hp感染阴性者。[结论]成人体检人群Hp感染者与系统性炎症指标密切相关,通过控制Hp感染,改善系统性炎症反应从而改善胃外疾病的进展是一个值得探索的方向。[Objective]To explore the association between Helicobacter pylori(Hp)infection and total white blood cell count and classification in a Chinese population.[Methods]Using cross-sectional research methods,adult health subjects who had undergone a^(13)C breath test at the Physical Examination Center of Wuhan Tongji Hospital from January to December 2017 were enrolled.Data on demographic information,physical measurement indexes,blood biochemical indexes,disease history and other characteristics were collected.Multiple linear regression analysis was performed to explore the relationship between Hp infection and systemic inflammation indicators.[Results]The total of 47261 subjects were enrolled,including 29137 men and 18124 women.Their age was(43.2±11.9)years;the prevalence rate of Hp infection was 27.2%.Compared with Hp negative subjects,Hp positive subjects had higher white blood cell count,neutrophil count,lymphocyte count,and neutrophil/lymphocyte ratio,while the platelet/lymphocyte ratio was lower.After adjusting for age,gender,BMI,hypertension,diabetes,hyperuricemia,and dyslipidemia,Hp infection was positively correlated with white blood cell count and negatively correlated with platelet/lymphocyte ratio(P<0.05).In addition,Hp infection was directly proportional to the white blood cell count and inversely proportional to the platelet/lymphocyte ratio.BMI and Hp infection had an interaction effect on the neutrophil/lymphocyte ratio(P=0.050).Among the subjects with BMI<24,the neutrophil/lymphocyte ratio of Hp-positive infection was higher than that of Hp-negative.[Conclusion]Pylori-infected subjects in adult physical examination population are closely related to systemic inflammatory indicators.Control of Hp infection may be useful in reducing the progress of the extra-gastric diseases.

关 键 词：炎症 幽门螺杆菌 白细胞 

分 类 号：R364.5[医药卫生—病理学]