齐拉西酮联合奥氮平对早期精神分裂症患者的效果  

The effect of ziprasidone combined olanzapine in the treatment of early schizophrenia patients

作　　者：翟瑛 赵会芬 耿小雨 ZHAI Ying;ZHAO Huifen;GENG Xiaoyu(Luoyang Fifth People's Hospital,Luoyang 471000,China)

机构地区：[1]洛阳市第五人民医院,洛阳471000

出　　处：《国际精神病学杂志》2021年第6期1025-1027,1042,共4页Journal Of International Psychiatry

基　　金：河南省医学科技攻关计划项目(编号:201702352)。

摘　　要：目的探讨早期精神分裂症患者采用齐拉西酮联合奥氮平治疗的价值。方法纳入120例早期精神分裂症患者(2019年8月~2021年6月),按"治疗方案"分为2组,以奥氮平治疗者60例纳入对照组,采用齐拉西酮+奥氮平治疗者60例纳入观察组,统计两组临床疗效、副反应量表(TESS)评分、阴性症状量表评分(SANS)、阳性症状量表评分(SAPS)等临床指标。结果(1)临床疗效:观察组98.33%,高于对照组的85.00%(P<0.05)。(2)SANS、SAPS评分:观察组低于对照组(P<0.05)。(3)TESS评分:观察组治疗后4周(7.27±2.88)分、治疗后8周(2.21±0.11)评分低于对照组(9.61±3.62)、(2.85±0.32)分(P<0.05)。(4)临床指标:观察组甘油三酯(Triglyceride,TG)、总胆固醇(Total cholesterol,TC)、低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)、血糖(Factry Business Customer,FBC)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素-2(Interleukin-2,IL-2)、白介素-6(Interleukin-6,IL-6)低于对照组(P<0.05)。结论齐拉西酮联合奥氮平对早期精神分裂症患者效果较好,可改善其阴性症状评分及副反应评分,亦可降低血糖及血脂水平。Objective To explore the value of ziprasidone combined olanzapine in the treatment of early schizophrenia.Methods 120 patients with early schizophrenia were included in the study(August 2019~June 2021).They were divided into two groups according to the"treatment scheme".60 patients treated with olanzapine were included in the control group and 60 patients treated with ziprasidone+olanzapine were included in the observation group.The clinical efficacy,Treatment Emergent Symptom Scale(TESS)scores and negative symptom scale scores of the two groups were counted.Results(1)Clinical efficacy:the observation group(98.33%)was higher than the control group(85.00%),and the comparison between groups was P<0.05.(2)Sans and saps scores:the observation group was lower than the control group,and the comparison between groups was P<0.05.(3)Tess score:the scores of the observation group at 4 weeks(7.27±2.88)and 8 weeks(2.21±0.11)after treatment were lower than those of the control group(9.61±3.62)and(2.85±0.32)(P<0.05).(4)Clinical indicators:triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),blood glucose(FBC)and tumor necrosis factor(TNF)in the observation group-α(tumor necrosis factor-α,TNF-α).The levels of interleukin-2(IL-2)and interleukin-6(IL-6)in the control group were lower than those in the control group(P<0.05).Conclusion The combination of ziprasidone and olanzapine is feasible in the treatment of early schizophrenia.It can improve its negative symptom score and side effect score,and reduce the level of blood glucose and blood lipid.

关 键 词：齐拉西酮 奥氮平 早期精神分裂症 阴性症状量表评分 副反应 

分 类 号：R749.3[医药卫生—神经病学与精神病学]