非酒精性脂肪性肝病体外模型的研究进展  

Research advances in in vitro models for nonalcoholic fatty liver disease

作　　者：卢晓臣 韩红梅[1] LU Xiaochen;HAN Hongmei(Department of Gastroenterology,The Affiliated Hospital of Yanbian University,Yanji,Jilin 133000,China)

机构地区：[1]延边大学附属医院消化内科,吉林延吉133000

出　　处：《临床肝胆病杂志》2022年第1期201-205,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81860110)。

摘　　要：非酒精性脂肪性肝病发病率逐年上升,其治疗手段有限,对其发病机制的研究是当前热点。为了更好地阐明其发病机制,迫切需要开发先进、安全、有效的体外模型或体内模型,以了解并制订针对该疾病的治疗策略。本文回顾了目前常用于非酒精性脂肪性肝病临床前研究的体外模型,并讨论了其各自的优缺点,为研究非酒精性脂肪性肝病发病机制及治疗提供理论依据。The incidence rate of nonalcoholic fatty liver disease(NAFLD)is increasing year by year,with limited treatment methods,and its pathogenesis is a research hotspot at present.In order to better clarify its pathogenesis,it is urgent to develop advanced,safe,and effective in vitro or in vivo models to understand and develop treatment strategies for this disease.This article reviews the in vitro models commonly used in the preclinical study of NAFLD and discusses their advantages and disadvantages,so as to provide a theoretical basis for the pathogenesis and treatment of NAFLD.

关 键 词：非酒精性脂肪性肝病 模型 理论 病理过程 治疗学 

分 类 号：R575.5[医药卫生—消化系统]