粪便免疫化学试验在结直肠癌早期诊断中应用的研究进展  

Research progress on application of fecal immunochemical test in early diagnosis of colorectal cancer

作　　者：孟凡一 周如琛 李延青[1,2] MENG Fanyi;ZHOU Ruchen;LI Yanqing(Department of Gastroenterology,Qilu Hospital of Shandong University,Jinan250012,China;Laboratory of Translational Gastroenterology,Qilu Hospital of Shandong University,Jinan250012,China)

机构地区：[1]山东大学齐鲁医院消化内科,山东济南250012 [2]山东大学齐鲁医院胃肠疾病转化医学实验室,山东济南250012

出　　处：《老年医学研究》2021年第6期40-45,共6页Geriatrics Research

基　　金：山东大学临床研究项目(2020SDUCRCA012,精准定量FIT对结直肠进展期腺瘤和结直肠癌早期诊断的研究)。

摘　　要：结直肠癌发病进展较慢,早期诊断至关重要。粪便免疫化学试验(FIT)改变了结直肠癌筛查的方式,相较于传统的愈创木酯法粪便潜血试验(gFOBT),FIT具有操作简便、灵敏度高、不需饮食限制等优点,已逐渐取代gFOBT成为结直肠癌筛查的主要手段。本文概述了FIT的检测原理、临床常见类型、对结直肠癌及癌前病变的诊断效能,并总结了影响FIT诊断效能的因素、应用过程的注意事项,以及未来的研究方向。Colorectal cancer progresses slowly and the early diagnosis is crucial.Fecal immunochemical test(FIT)has changed the way of colorectal cancer screening.Compared with traditional Guaiac-based fecal occult blood test(gFOBT),FIT has the advantages of simple operation,high sensitivity and no dietary restriction,and has gradually replaced gFOBT as the main method of colorectal cancer screening.This review described the detection principle,common clinical types,diagnostic efficacy of FIT for colorectal cancer and precancerous lesions,and summarized the factors affecting the diagnostic efficacy of FIT,the precautions in the application process,and research directions in the future.

关 键 词：粪便免疫化学试验 愈创木酯法粪便潜血试验 结直肠癌 进展期腺瘤 人群筛查 

分 类 号：R735.35[医药卫生—肿瘤]