肿瘤糖酵解途径中关键限速酶及其调节因子的研究进展  

Advances in key rate-limiting enzymes and their regulatory factors in the glycolysis pathway of tumors

作　　者：王敏 汪橙橙 杨振芳 张亚楠 WANG Min;WANG Cheng-cheng;YANG Zhen-fang;ZHANG Ya-nan(School of Nursing,and,Shandong University of Traditional Chinese Medicine;College of Traditional Chinese Medicine,and,Shandong University of Traditional Chinese Medicine;Department of Pathology,Shandong University of Traditional Chinese Medicine;Shandong Traditional Chinese Medicine Classic Prescription Cooperative Innovation Center,Ji'nan 250355,China)

机构地区：[1]山东中医药大学护理学院,山东济南250355 [2]山东中医药大学中医学院,山东济南250355 [3]山东中医药大学病理教研室,山东济南250355 [4]山东省中医经典名方协同创新中心,山东济南250355

出　　处：《解剖科学进展》2021年第6期755-758,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81703839);山东省高校科研计划重点项目(J17KA243);山东省中医药科技发展计划项目(2015-016,2017-009);山东中医药大学2019年国家级大学生创新创业训练计划项目(201910441009);山东中医药大学2019年省级大学生创新创业训练计划项目(S201910441001,S201910441016)。

摘　　要：恶性肿瘤细胞与正常分化细胞相比有着不同的能量代谢表型,恶性肿瘤最显著的特征之一是有氧糖酵解,又称为糖酵解或Warburg效应。Warburg效应普遍存在于各种恶性肿瘤中,且糖酵解的活跃程度与催化糖酵解的酶有密切联系,己糖激酶2(HK2)、6-磷酸果糖激酶1(PFK1)、M2型丙酮激酶(PKM2)等糖酵解关键酶的表达与活性可影响肿瘤细胞的糖酵解,进而影响肿瘤的增殖。Compared with normal differentiated cells, malignant tumor cells have different energy metabolism phenotypes. One of the most prominent characteristics of malignant tumors is aerobic glycolysis, also known as glycolysis or Warburg effect. Warburg effect is ubiquitous in various malignant tumors, and the activity of glycolysis in malignant tumors is closely related to the enzymes catalyzing glycolysis. Hexokinase-2(HK2), fructose-6-phosphate kinase-1(PFK1), M 2 pyruvate kinase M2(PKM2) and other key enzymes are involved in glycolysis. The expression and activity can affect the glycolysis of cancer cells, and then affect the proliferation of cancer.

关 键 词：有氧糖酵解 糖酵解途径 恶性肿瘤 分化细胞 调节因子 活跃程度 代谢表型 

分 类 号：R730.2[医药卫生—肿瘤]