雷贝拉唑与奥美拉唑分别联合克拉霉素、阿莫西林治疗胃溃疡的临床对比研究  

Clinical Comparative Study on Curative Effect of Rabeprazole and Omeprazole Respectively Combined with Clarithromycin and Amoxicillin on Gastric Ulcer

作　　者：李想[1] 王晓娜[1] LI Xiang;WANG Xiao-na(Department of Gastroenterology,the Third People's Hospital of Zhengzhou,Zhengzhou 450000,Henan Province,China)

机构地区：[1]郑州市第三人民医院消化内科,河南郑州450000

出　　处：《罕少疾病杂志》2022年第2期74-75,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨雷贝拉唑与奥美拉唑分别联合克拉霉素、阿莫西林治疗胃溃疡的临床药效。方法利用随机信封法将本院2019年3月至2020年3月治疗的112例胃溃疡患者分为对照组、观察组,各56例,对照组进行奥美拉唑联合克拉霉素、阿莫西林治疗,观察组进行雷贝拉唑联合克拉霉素、阿莫西林治疗。治疗6周后观察治疗效果,并在治疗前后对患者血清炎症因子进行测定。结果观察组有效率91.07%,显著高于对照组(71.43%,P<0.05);治疗后患者C反应蛋白(CRP)、白细胞介素-6(IL-6)水平明显上升,白细胞介素-2(IL-2)明显下降(P<0.05),且观察组变化幅度更为明显,有统计学差异(P<0.05)。结论雷贝拉唑联合克拉霉素、阿莫西林相比奥美拉唑联合克拉霉素、阿莫西林治疗胃溃疡效果更佳明显,能明显改善患者血清炎症因子水平。Objective To explore the clinical curative effect of rabeprazole and omeprazole respectively combined with clarithromycin and amoxicillin on gastric ulcer. Methods The 112 patients with gastric ulcer who were treated in the hospital from March 2019 to March 2020 were divided into control group and observation group by random envelope method, 56 cases in each group. The control group was treated with omeprazole combined with clarithromycin and amoxicillin, while observation group was treated with rabeprazole combined with clarithromycin and amoxicillin. After 6 weeks of treatment, curative effect was observed. The serum inflammatory factors before and after treatment were measured. Results The response rate in observation group was significantly higher than that in control group [(91.07% vs. 71.43%),(P<0.05)].After treatment, the levels of C-reactive protein(CRP) and interleukin-6(IL-6) in observation group were significantly increased, while interleukin-2(IL-2) was significantly decreased in both groups(P<0.05). And the change amplitude in observation group was more significant than control group(P<0.05). Conclusion Compared with omeprazole, curative effect of rabeprazole combined with clarithromycin and amoxicillin is better on gastric ulcers, which can significantly improve levels of serum inflammatory factors.

关 键 词：胃溃疡 奥美拉唑 阿莫西林 炎症因子 

分 类 号：R573[医药卫生—消化系统] R364.5[医药卫生—内科学]