回顾性分析三消饮加减方治疗轻型/普通型新型冠状病毒肺炎患者的临床疗效  

Clinical Efficacy of Modified Sanxiaoyin in Treatment of Mild or Moderate COVID-19 Patients:Based on Retrospective Analysis

作　　者：罗志辉 王昆秀 张艳琳 陈子琴 陈贝 陈佳[1] 周婷[1] 顾骁磊 李崇立 闫鹏 田玲玲 徐驰成 陈柏霖 陈松[1,2] 祁青 LUO Zhi-hui;WANG Kun-xiu;ZHANG Yan-lin;CHEN Zi-qin;CHEN Bei;CHEN Jia;ZHOU Ting;GU Xiao-lei;LIC hong-li;YAN Peng;TIAN Ling-ling;XU Chi-cheng;CHEN Bo-lin;CHEN Song;QI Qing(Hubei University of Chinese Medicine,Wuhan 430061,China;The Second Hospital of Jingzhou,Jingzhou 434000,China;Obstetrics and Gynecology Hospital ofFudan University,Shanghai 200011,China)

机构地区：[1]湖北中医药大学,武汉430061 [2]荆州市第二人民医院,湖北荆州434000 [3]复旦大学附属妇产科医院,上海200011

出　　处：《中国实验方剂学杂志》2022年第1期150-156,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局中医药传承与创新项目(岐黄工程)(国中医药人教函[2018]284号);湖北省青年英才开发计划项目(鄂青联发[2020]1号);湖北中医名师工作室项目(鄂卫生计生通报[2018]15号);荆州市2019年医疗卫生科技计划项目(2019HC51);荆州市科技创新智库研究课题(JZCXZK202002);2020年度湖北中医药大学针灸治未病湖北省协同创新中心项目(HBPCIC-2020-12)。

摘　　要：目的:回顾性分析52例新型冠状病毒肺炎(COVID-19)感染患者临床资料,观察三消饮加减方治疗轻型/普通型COVID-19患者的临床疗效。方法:采用倾向性评分匹配法,收集2019年12月至2020年5月在荆州市第二人民医院救治定点医院就诊的轻型/普通型确诊患者临床资料,将符合纳入和排除标准的应用三消饮加减方治疗的26例患者设立为观察组,按1∶1配对常规治疗26例患者为对照组。比较两组临床症状消失情况、主要症状消失时间、中医症状疗效评价及住院时间、实验室检测指标和CT影像学变化情况。结果:两组一般资料比较差异均无统计学意义,具有可比性。治疗7 d后,观察组发热、咳嗽、乏力、咽干、纳差、精神欠佳、睡眠差症状消失率明显高于对照组(P<0.05),咯痰、胸闷症状消失率两组间比较差异无统计学意义。在症状消失病例统计中,观察组主要症状(发热、咳嗽、乏力、咽干、纳差、胸闷)平均消失时间均显著短于对照组(P<0.01);治疗7 d后,两组中医症状量表评分均显著下降(P<0.01),观察组降低程度显著优于对照组(P<0.01);两组患者治疗后均痊愈出院,观察组平均住院时间(12.79±2.68)d,显著少于对照组平均住院时间(15.27±3.11)d,差异有统计学意义(P<0.01);观察组治疗有效率为92.31%(24/26),高于对照组的76.92%(20/26),但差异无统计学意义;治疗7 d后,两组淋巴细胞计数(LYM)均显著升高(P<0.01),血细胞沉降率(ESR),C反应蛋白(CRP)和降钙素原(PCT)水平均显著降低(P<0.01),观察组下降程度较对照组显著(P<0.01);治疗7d后,观察组CT影像改善总有效率为90.00%(18/20),高于对照组的77.27%(17/22),但差异无统计学意义;观察组肺部阴影改善情况明显优于对照组(P<0.01)。结论:三消饮加减方能明显减轻COVID-19轻型/普通型患者的发热、咳嗽、乏力、纳差、胸闷、睡眠不佳等症状,改善生化指标,促进肺功能的恢复,为�Objective: To retrospectively analyze the clinical data of 52 patients with coronavirus disease-2019(COVID-19) and explore the clinical efficacy of modified Sanxiaoyin on mild/moderate COVID-19 patients. Method: The propensity score matching method was used to collect the clinical data of mild or moderate COVID-19 patients enrolled in the designated hospital of the Second Hospital of Jingzhou from December 2019 to May 2020. A total of 26 eligible patients who were treated with modified Sanxiaoyin were included in the observation group,and the 26 patients treated with conventional method were the regarded as the control. The disappearance of clinical symptoms,disappearance time of main symptoms,efficacy on traditional Chinese medicine(TCM)symptoms,hospitalization duration,laboratory test indicators,and CT imaging changes in the two groups were compared. Result: The general data in the two groups were insignificantly different and thus they were comparable. After 7 days of treatment,the disappearance rate of fever,cough,fatigue,dry throat,anorexia,poor mental state,and poor sleep quality in the observation group was higher than that in the control group(P<0.05),and the difference in the disappearance rate of expectoration and chest distress was insignificant. For the cases with the disappearance of symptoms,the main symptoms(fever,cough,fatigue,dry throat,anorexia,chest distress)disappeared earlier in the observation group than in the control group(P<0.01). After 7 days of treatment,the scores of the TCM symptom scale of both groups decreased(P<0.01),and the decrease of the observation group was larger that of the control group(P<0.01).All patients in the two groups were cured and discharged. The average hospitalization duration in the observation group[(12.79±2.68)d]was shorter than that in the control group[(15.27±3.11)d](P<0.01). The effective rate in the observation group(92.31%,24/26)was higher than that in the control group(76.92%,20/26). After7 days of treatment,the lymphocyte(LYM)count increased(P<0.05),a

关 键 词：三消饮加减方 新型冠状病毒肺炎 临床研究 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学]