胰腺癌精准术前评估的现状及挑战  

Current status and challenges of accurate preoperative assessment of pancreatic cancer

作　　者：周雨 孔瑶 陈汝福 Zhou Yu;Kong Yao;Chen Rufu(Department of Pancreatic Surgery,Guangdong Provincial People′s Hospital(Guangdong Academy of Medical Sciences),Guanghzou 510080,China)

机构地区：[1]广东省人民医院(广东省医学科学院)胰腺中心,广州510080

出　　处：《中华外科杂志》2022年第1期22-26,共5页Chinese Journal of Surgery

基　　金：国家自然科学基金(82072639)。

摘　　要：胰腺癌是致死率极高的恶性肿瘤。历经百余年的发展,胰腺癌的外科治疗技术虽然取得了显著进步,但对患者的生存改善仍差强人意。随着肿瘤治疗理念的发展、精准医学的兴起,以外科为中心的多学科团队诊疗模式逐步成为主流,做好胰腺癌的术前精准评估成为进一步改善患者预后的突破口。本文着重从精准评估的角度,对胰腺癌的术前诊断与分期、可切除性的综合评估、新辅助治疗策略的选择,以及新辅助治疗效果评估等方面的进展进行综述,并探讨其中的不足与挑战,以期使胰腺癌的术前评估更加精准、全面,并为将来的研究提供参考。Pancreatic cancer is a malignant tumor with very poor prognosis.In the past decade,the surgical technique has made significant progress,but it has not brought desired effect in improving the survival outcome of pancreatic cancer patients.With the development of the concept of cancer treatment and the emergence of precision medicine,the surgical centered multidisciplinary treatment and collaborative diagnosis and treatment mode has gradually become the mainstream.Accurate preoperative assessment of pancreatic cancer has become a breakthrough for further improving the prognosis of patients with pancreatic cancer.From the perspective of precise assessment,this paper mainly summarized the status and progress on the following four aspects:the preoperative diagnosis and staging,the resectability evaluation,the neoadjuvant therapy strategy and efficacy evaluation of neoadjuvant therapy in pancreatic cancer,and also discussed the shortcomings and challenges in the field of precise assessment,finally in order to make the preoperative assessment of pancreatic cancer more precise and standard,and to provide useful reference for future research work.

关 键 词：胰腺肿瘤 外科手术 精准医学 可切除性评估 新辅助治疗 

分 类 号：R735.9[医药卫生—肿瘤]