顽固感染根管内粪肠球菌的致病机制及其控制方法进展  

Research progress in pathogenesis and control of Enterococcus faecalis with persistent infection in root canals

作　　者：胡涛[1] 雷蕾[1] 周学东[1] Hu Tao;Lei Lei;Zhou Xuedong(West China Hospital of Stomatology,Sichuan University&State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医院,口腔疾病研究国家重点实验室国家,口腔疾病临床医学研究中心,成都610041

出　　处：《中华口腔医学杂志》2022年第1期10-15,共6页Chinese Journal of Stomatology

基　　金：国家自然科学基金(81870754)。

摘　　要：根管治疗是治疗牙髓感染的常用方法。成功的根管治疗依赖于良好的根管预备、冲洗消毒以及对三维根管系统的严密充填,其中通过清除根管系统内感染生物膜、细菌毒素以防止高度复杂的根管系统再次感染是根管治疗成功的关键。本文从根管内严苛环境下粪肠球菌的致病机制、根管顽固感染的根尖周组织炎症与局部免疫、感染根管控制方法进展等方面,对这一主题进行阐述。Root canal therapy is the common treatment for endodontic infections.Successful root canal therapy depends on favorable root canal preparation,root canal medication and three-dimensional obturation of the root canal system.The key to successful root canal therapy is to prevent re-infection of the highly complex root canal systems by removing infecious biofilms and bacterial toxins in the root canal system.The present paper reviews the pathogenic mechanism of the Enterococcus faecalis in the harsh environment of root canal system,the inflammation and immunity of refractory periapical periodontitis and the progress of infection control methods.

关 键 词：根管疗法 根管制备 肠球菌 粪 生物膜 感染根管 免疫 

分 类 号：R781.05[医药卫生—口腔医学]