宫颈癌患者五年生存及影响因素分析  

Analysis of 5-year survival and its influencing factors of patients with cervical cancer

作　　者：张艺艺 李奇 刘旭 王亚楠[1] 邹沅杰 周慧慧[1,3] 徐春燕 苏升琦 葛鑫 王铜 ZHANG Yiyi;LI Qi;LIU Xu;WANG Yanan;ZOU Yuanjie;ZHOU Huihui;XU Chunyan;SU Shengqi;GE Xin;WANG Tong(Institute of Keshan Disease,Chinese Center for Endemic Disease Control,Harbin Medical University,Harbin 150081,China;Harbin Medical University Cancer Hospital;Jining Medical University;Tarim University)

机构地区：[1]哈尔滨医科大学地方病控制中心克山病研究所,哈尔滨150081 [2]哈尔滨医科大学附属肿瘤医院 [3]济宁医学院 [4]塔里木大学

出　　处：《实用肿瘤学杂志》2022年第1期7-13,共7页Practical Oncology Journal

基　　金：黑龙江省博士后科研启动金(编号:LBH-Q17096);哈医大肿瘤医院海燕基金重点项目(编号:JJZD2021-16)。

摘　　要：目的观察宫颈癌患者生存与病情进展状态,并探究其影响因素,为改善预后提供依据。方法本研究纳入2013年1月—2015年12月于哈尔滨医科大学附属肿瘤医院就诊的2306例宫颈癌患者,对其进行回顾和随访,采用Kaplan-Meier法分析宫颈癌患者总生存期(OS)和无进展生存期(PFS),用Cox风险比例回归模型分析生存期影响因素。结果Ⅰ、Ⅱ、Ⅲ、Ⅳ期患者5年生存率分别为87.3%、79.3%、61.8%、36.8%;5年无进展生存率为82.9%、73.0%、55.6%和0。中位随访时间为51.0个月,单因素分析显示发病年龄、绝经情况、产次数、孕次数、心脏病史、流产史、淋巴结状态、脉管癌栓、FIGO分期、精神、饮食状态和末产年龄与患者OS和PFS有关。多因素分析显示末产年龄、淋巴结状态、脉管癌栓和间质层浸润程度是影响OS和PFS的独立因素。结论除病理特征外,多孕、多产和末产年龄大也是宫颈癌患者预后不良的危险因素。Objective This study aimed to observe the survival and progress of patients with cervical cancer,and to explore its influencing factors,so as to provide evidence for improving the prognosis.Methods A total of 2306 cervical cancer patients hospitalized in Harbin Medical University Cancer Hospital between January 2013 and December 2015 were included for reviewed and followed up.The Kaplan-Meier method was used to analyze the overall survival and progression-free survival of cervical cancer patients.The Cox risk proportional regression model was used to analyze the influencing factors of survival.Results The 5-year survival rates of stageⅠ,Ⅱ,ⅢandⅣpatients were 87.3%,79.3%,61.8%,and 36.8%,respectively;the 5-year progression-free survival rates were 82.9%,73.0%,55.6%,and 0,respectively.The median follow-up time was 51.0 months.Univariate analysis showed that the age of diagnosis,menopausal status,the number of births,history of heart disease,the history of abortion,lymph node status,vascular cancer thrombus,FIGO staging,mentality,diet status,and age of final delivery,etc.were related to the patient′s OS and PFS.Multivariate analyses showed that age at final delivery,lymph node status,vascular tumor thrombus and the degree of interstitial invasion were independent factors that affected the OS and PFS.Conclusion In addition to pathological features,multiple pregnancy,multiple births,and older age at final delivery are risks factors for poor prognosis of the patients with cervical cancer.

关 键 词：宫颈癌 随访 总生存期 无进展生存期 疗效比较学研究 

分 类 号：R737.33[医药卫生—肿瘤]