HPIP在子宫内膜癌中高表达及其在生存预后分析中的意义  

High expression of HPIP in endometrial carcinoma and its significance in the analysis of survival and prognosis

作　　者：王榆平 思美丽 孙小霞 郭玉琳[1] WANG Yuping;SI Meili;SUN Xiaoxia;GUO Yulin(The Second Hospital of Yulin City,Yulin 719000,China)

机构地区：[1]陕西省榆林市第二医院妇科,榆林719000

出　　处：《实用肿瘤学杂志》2022年第1期44-48,共5页Practical Oncology Journal

摘　　要：目的研究造血前B细胞白血病转录因子相互作用蛋白(Hematopoietic pre-B-cell leukemia transcription factor interacting protein,HPIP)在子宫正常内膜组织、子宫内膜非典型增生组织和子宫内膜癌组织中的表达情况及其在临床预后中的意义。方法采用免疫组化方法检测26例子宫正常内膜组织、30例子宫内膜非典型增生组织和122例子宫内膜癌组织中HPIP蛋白表达情况。分析HPIP在子宫内膜癌组织中的表达情况与其临床病理特征、患者无病生存期(Disease-free survival,DFS)和总生存期(Overall survival,OS)的相关性。结果HPIP在子宫正常内膜组织和子宫内膜非典型增生组织的表达显著低于在子宫内膜癌组织中的表达(P<0.05);HPIP在子宫内膜癌组织中的表达程度与组织学分级、FIGO分期、淋巴结转移密切相关(P<0.05);在子宫内膜癌患者中HPIP高表达患者的DFS和OS显著低于HPIP低表达的患者(P<0.05)。结论HPIP蛋白有望成为预测子宫内膜患者预后的生物学标志物,并有可能作为子宫内膜癌治疗的一个潜在靶点。Objective The aim of this study was to investigate the expression of hematopoietic pre-B-cell leukemia transcription factor(PBX)-interacting protein(HPIP)in normal endometrial tissues,endometrial atypical hyperplasia tissues and endometrial cancer tissues,and its clinical prognostic significance.Methods Immunohistochemical method was used to detect the expression of HPIP protein in 26 normal uterine endometrial tissues,30 endometrial atypical hyperplasia tissues and 122 endometrial cancer tissues.The correlation amongst the expression of HPIP in endometrial cancer tissues and its clinicopathological factors,disease-free survival(DFS)and overall survival(OS)were analyzed.Results The expression of HPIP in normal endometrial tissues and endometrial atypical hyperplasia tissues was significantly lower than that in endometrial cancer tissues,normal endometrial tissues and endometrial atypical hyperplasia tissues,the differences were statistically significant(P<0.05).The expression of HPIP in endometrial cancer tissues was closely related to its histological grade,federation international of gynecology and obstetrics(FIGO)staging and lymph node metastasis(P<0.05).Endometrial cancer patients with high expression of HPIP had significantly shorter DFS and OS than those with low expression of HPIP(P<0.05).Conclusion HPIP protein may be a very valuable biomarker,which can be used to interfere with the prognosis of patients with endometrial cancer,and may be used as a potential target for cancer treatment of endometrial cancer.

关 键 词：造血前B细胞白血病转录因子相互作用蛋白 子宫内膜癌 免疫组化 临床预后 

分 类 号：R737.33[医药卫生—肿瘤]