组织标本中组蛋白去乙酰化酶6蛋白水平与子宫内膜癌患者临床病理特征的关系  

Relationship between Histone Deacetylase 6 Protein Level in Tissue Samples and Clinicopathological Features of Patients with Endometrial Cancer

作　　者：宋燕 马成斌 李冰 吴慧恒 吴琼蔚 SONG Yan;MA Cheng-bin;LI Bing(Shanghai Changning Maternity and Infant Health Hospital,Shanghai,200050 China)

机构地区：[1]上海市长宁区妇幼保健院妇科,上海200050 [2]上海市长宁区妇幼保健院病理科,上海200050

出　　处：《医学临床研究》2021年第12期1780-1783,共4页Journal of Clinical Research

基　　金：上海市长宁区科委项目(CNKW2017Y16)。

摘　　要：【目的】探讨组织标本中组蛋白去乙酰化酶6(HDAC6)蛋白水平与子宫内膜癌患者临床病理特征的关系。【方法】选取2018年3月至2020年3月在本院手术治疗的90例子宫内膜癌患者作为研究对象,取所有患者手术后癌组织与癌旁正常组织标本,采用免疫组织化学染色法测定组织标本中HDAC6蛋白表达情况,比较所有患者癌组织和癌旁正常组织中HDAC6蛋白阳性检出率及不同临床病理特征的子宫内膜癌患者癌组织中HDAC6蛋白表达情况。【结果】子宫内膜癌患者癌组织中HDAC6蛋白阳性检出率显著高于癌旁组织(P<0.05)。不同年龄、病理分型、组织学分级及是否宫颈累及的子宫内膜癌患者癌组织中HDAC6蛋白阳性检出率比较差异无统计学意义(P>0.05);Ⅲ~Ⅳ期患者HDAC6蛋白阳性检出率显著高于Ⅰ~Ⅱ期患者(P<0.05);淋巴结转移患者HDAC6蛋白阳性检出率显著高于非淋巴结转移患者(P<0.05);肌层浸润≥1/2患者HDAC6蛋白阳性检出率显著高于肌层浸润<1/2患者(P<0.05)。【结论】子宫内膜癌患者癌组织中HDAC6蛋白表达上调,其表达水平与患者FIGO分期、淋巴结转移、肌层浸润深度密切相关。【Objective】To investigate the relationship between histone deacetylase 6(HDAC6)protein level in tissue samples and clinicopathological features of patients with endometrial cancer.【Methods】A total of 90 patients with endometrial cancer who underwent surgery in our hospital from March 2018 to March 2020 was selected as the research objects.The specimens of cancer tissues and adjacent normal tissues of all patients after surgery were taken,and the expression of HDAC6 protein in tissue samples was measured by immunohistochemical staining.The positive rate of HDAC6 protein in cancer tissues and adjacent normal tissues of all patients and the expression of HDAC6 protein in cancer tissues of endometrial cancer patients with different clinicopathological features were compared.【Results】The positive rate of HDAC6 protein in endometrial carcinoma was significantly higher than that in adjacent tissues(P<0.05).There was no significant difference in the positive rate of HDAC6 protein in endometrial cancer patients with different age,pathological classification,histological grade and cervical involvement(P>0.05);The positive rate of HDAC6 protein in patients with stageⅢ~Ⅳwas significantly higher than that in patients with stageⅠ~Ⅱ(P<0.05);The positive rate of HDAC6 protein in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis(P<0.05);The positive rate of HDAC6 protein in patients with myometrial infiltration≥1/2 was significantly higher than that in patients with myometrial infiltration<1/2(P<0.05).【Conclusion】The expression of HDAC6 protein is up-regulated in endometrial carcinoma,and its expression level is closely related to FIGO stage,lymph node metastasis and myometrial invasion depth.

关 键 词：子宫内膜肿瘤/病理学 Ⅲ型组蛋白脱乙酰基酶类 肿瘤分期 预后 

分 类 号：R737.33[医药卫生—肿瘤]