脑源性神经营养因子对卒中后抑郁的早期诊断价值  

The diagnostic value of serum BDNF levels in post-stroke depression

作　　者：金晓梅 王贤慧[1] 刘晓蓉 王飞鸿 何晓燕[1] 翟万庆[1] JIN Xiaomei;WANG Xianhui;LIU Xiaorong;WANG Feihong;HE Xiaoyan;ZHAI Wanqing(Department of Neurology,Taicang First People’s Hospital,Taicang 215400,China)

机构地区：[1]太仓市第一人民医院神经内科,江苏太仓215400

出　　处：《安徽医学》2022年第1期40-43,共4页Anhui Medical Journal

基　　金：苏州市科技计划项目(项目编号:SYSD2019033);苏州市临床重点病种诊疗项目(项目编号:LCZX201924)。

摘　　要：目的探讨血清脑源性神经营养因子(BDNF)对卒中后抑郁(PSD)的早期诊断价值。方法选取2020年1~6月在江苏省太仓市第一人民医院就诊的脑卒中患者120例,其中合并有卒中后抑郁60例患者作为PSD组,不合并抑郁的60例患者作为对照组。比较两组患者BDNF差异性,采用受试者工作特征曲线评价其诊断价值。结果PSD组患者血清BDNF水平为(11.33±3.93)ng/mL,低于对照组,HAMD评分为(29.38±5.05)分,高于对照组,差异均有统计学意义(P<0.05);BDNF对早期诊断PSD的受试者工作特征曲线下面积、灵敏度、特异度分别为0.950、91.67%和90.00%。结论BDNF对PSD具有良好的早期诊断效能。Objective To evaluate the diagnostic value of serum brain-derived neurotrophic factor(BDNF)inpost-stroke depression(PSD).Methods A total of 120 stroke patients who were treated at the First People’s Hospital of Taicang City,Jiangsu Province from January to June 2020 were collected.Among them,60 patients with PSD were enrolled in the PSD group,and 60 patients without depression were enrolled in the control group.The differences in BDNF between the two groups were compared,and the diagnostic value was evaluated by quoting the receiver operating curve.Results The level of serum BDNF in PSD group was(11.33±3.93)ng/mL,lower than that in the control group(P<0.05),and the HAMD score was(29.38±5.05),higher than that in the control group(P<0.05).The area under receiver operating curve,sensitivity and specificity of BDNF for early diagnosis of PSD was 0.950%,91.67%and 90.00%,respectively.Conclusion Serum BDNF hasa good early diagnostic efficacy for PSD.

关 键 词：脑源性神经营养因子 卒中 抑郁 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]