婴幼儿维生素D营养状况与贫血的关系研究  

Relationship between vitamin D status and anemia in infants

作　　者：罗辉[1] 李晖[1] 王思月 罗有文[1] 梅世伟[1] Luo Hui;Li Hui;Wang Siyue;Luo Youwen;Mei Shiwei(Department of Radiology,Guangdong Woman and Children's Health Hospital,Guangzhou 511440,China)

机构地区：[1]广东省妇幼保健院放射科,广州511440

出　　处：《国际医药卫生导报》2022年第1期100-103,共4页International Medicine and Health Guidance News

摘　　要：目的了解广州地区婴幼儿维生素D营养状况及贫血状况,探讨维生素D营养状况与贫血的关系,为婴幼儿维生素D缺乏性疾病防治提供科学依据,为婴幼儿贫血预防提供参考。方法采用现况研究,调查2018年于广东省妇幼保健院健康体检的婴幼儿8530名(男4935名,女3595名,3~36月龄),采集血样,检测25-羟维生素D[25-hydroxyvitaminD,25(OH)D]和血红蛋白水平。采用t检验、χ^(2)检验、χ^(2)趋势检验,相关性采用Pearson相关分析。结果婴幼儿血清25(OH)D水平为(81.05±25.41)nmol/L,不同性别婴幼儿的25(OH)D水平差异无统计学意义;婴幼儿维生素D缺乏率为7.68%(655/8530)、不足率为37.47%(3196/8530),不同性别维生素D营养状况差异无统计学意义。婴幼儿血清25(OH)D水平随月龄增长呈下降趋势,维生素D缺乏率及不足率随月龄的增长而升高(χ^(2)趋势=143.200,P<0.001)。婴幼儿血红蛋白水平为(118.68±10.30)g/L,不同性别血红蛋白水平差异无统计学意义;不同性别婴幼儿贫血检出率差异也无统计学意义。婴幼儿血红蛋白水平随月龄增长呈上升趋势,贫血检出率随月龄增长而降低(χ^(2)趋势=446.532,P<0.001)。婴幼儿维生素D缺乏组或不足组血红蛋白水平均低于维生素D充足组,维生素D缺乏组或不足组贫血检出率均高于维生素D充足组,差异有统计学意义(P<0.05)。血清25(OH)D水平与血红蛋白水平呈正相关(r=0.149,P<0.001)。结论广州地区6~36月龄婴幼儿维生素D不足率较高,血清25(OH)D与血红蛋白水平呈正相关,维生素D缺乏或不足可能与贫血有关,应采取合理措施改善婴幼儿维生素D营养状况,减少贫血发生,促进婴幼儿的健康成长。Objective To understand the relationship between vitamin D status and anemia in infants in Guangzhou,and to provide measures for the prevention of vitamin D deficiency and references for the prevention of anemia in infants.Methods A cross-sectional analysis was used to investigated 8530 infants who were 3-36 months old and took physical examination at Guangdong Woman and Children's Health Hospital in 2018,including 4935 boys and 3595 girls.Their blood samples were collected for the detection of 25-hydroxy vitamin D and hemoglobin.t test,χ^(2) test,χ^(2) trend test,and Pearson correlation analysis were applied.Results The level of 25-hydroxy vitamin D was(81.05±25.41)nmol/L in the infants.There was no statistical difference in the level of 25-hydroxy vitamin D between the boys and the girls(P>0.05).The incidences of vitamin D deficiency and insufficiency were 7.68%(655/8530)and 37.47%(3196/8530).There was no statistical difference in vitamin D status between the boys and the girls(P>0.05).As the infants was elder,the serum level of 25-hydroxy vitamin D was lower(P<0.05),and the incidences of vitamin D deficiency and insufficiency were higher(χ^(2) trend=143.200,P<0.001).The level of hemoglobin was(118.68±10.30)g/L in the infants.There were no statistical differences in the level of hemoglobin and the detection rate of anemia between the boys and the girls(both P>0.05).As the infants were elder,the level of hemoglobin was higher and the detection rate of anemia was lower(χ^(2) trend=446.532,P<0.001).The levels of hemoglobin in the vitamin D deficiency group and the vitamin D insufficiency group were lower than that in the vitamin D sufficiency group(P<0.05).The incidences of anemia in the vitamin D deficiency group and the vitamin D insufficiency group were higher than that in the vitamin D sufficiency group(P<0.05).The level of 25-hydroxy vitamin D was positively correlated with the hemoglobin level in the infants(r=0.149,P<0.001).Conclusions The incidence of vitamin D insufficiency is high in 6-36 months ol

关 键 词：维生素D 贫血 婴幼儿 25-羟维生素D 

分 类 号：R153.2[医药卫生—营养与食品卫生学] R725.5[医药卫生—公共卫生与预防医学]