急性胰腺炎肠道微生态的研究进展  

The research progress on gut microbiota in acute pancreatitis

作　　者：龚亮 宋晓[2] 苏磊 吴东 Gong Liang;Song Xiao;Su Lei;Wu Dong(Department of Gastroenterology,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Emergency,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;NHC Key Laboratory of Human Disease Comparative Medicine,Institute of Medical Laboratory Animal Science,Chinese Academy of Medical Sciences(CAMS),Beijing 100021,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院消化内科,疑难重症及罕见病国家重点实验室,100730 [2]中国医学科学院,北京协和医学院,北京协和医院急诊科,100730 [3]中国医学科学院,医学实验动物研究所,卫健委人类疾病比较医学重点实验室,北京100021

出　　处：《中华临床营养杂志》2021年第5期308-314,共7页Chinese Journal of Clinical Nutrition

基　　金：国家自然科学基金资助项目面上项目(3217050539);北京市自然科学基金资助项目(7192162);中国医学科学院临床与转化医学研究基金资助项目(2019XK320036)。

摘　　要：肠道微生态与人体健康密切相关。越来越多研究证据表明,肠道菌群的变化在急性胰腺炎的发生、发展中起重要作用。探索肠道菌群在急性胰腺炎发病机制中的具体作用,可能有助于制定新的治疗策略,改善急性胰腺炎的预后。该文就肠道微生态对急性胰腺炎发病机制和治疗作用的最新研究进展进行综述。Gut microbiota is closely related to human health.Increasing evidence has indicated that alterations of gut flora play an important role in the occurrence and development of acute pancreatitis.Exploration of the specific effects of gut microbiota on the pathogenesis of acute pancreatitis may help to develop novel therapeutic strategies and improve the prognosis of acute pancreatitis.Here we reviewed and summarized the research progress regarding the role of the gut microbiota in the pathogenesis and treatment of acute pancreatitis.

关 键 词：急性胰腺炎 肠道微生态 菌群失调 

分 类 号：R576[医药卫生—消化系统]