基于呼出气挥发性有机物检测的肺癌筛查技术研究进展  

Research Progress of Lung Cancer Screening Technology Based on Detection of Exhaled Volatile Organic Compounds

作　　者：李杨[1,2,3] 李庆运 徐楚婷[1,2,3] 阮慧文 赵琨 花磊 李海洋[1,2,3] LI Yang;LI Qing-Yun;XU Chu-Ting;RUAN Hui-Wen;ZHAO Kun;HUA Lei;LI Hai-Yang(CAS Key Laboratory of Separation and Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China;Dalian Engineering Research Center of Breath Diagnostic Technology,Dalian 116023,China;Dalian Key Laboratory for Online Analytical Instrumentation,Dalian 116023,China;PCAB Research Center of Breath and Metabolism,Beijing 100074,China)

机构地区：[1]中国科学院大连化学物理研究所,中国科学院分离分析化学重点实验室,大连116023 [2]大连市呼出气诊断技术工程研究中心,大连116023 [3]大连市在线谱学分析仪器重点实验室,大连116023 [4]呼吸代谢研究中心,北京100074

出　　处：《分析化学》2022年第2期183-197,共15页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.22027804);辽宁省“兴辽英才计划”项目(No.XLYC1808022);大连市高层次人才创新支持计划项目(No.2019RQ101)资助。

摘　　要：肺癌已成为当前全球发病率和死亡率最高的癌症。早期肺癌的治愈率高,“早诊早治”已成为共识。呼出气检测具有非侵入性、取样方便且对人体友好的优势,通过对呼出气中特征代谢物的检测,寻找早期肺癌的疾病标志物,有望作为一种简单有效的早期肺癌筛查手段而备受关注。本文从临床常用肺癌筛查方法、呼出气组分及肺癌标志性挥发性有机物(VOCs)种类、呼出气VOCs收集方法、前处理方法以及肺癌标志性VOCs检测技术等方面,评述了基于呼出气VOCs检测的肺癌早期筛查技术的研究进展,并对其存在的问题和未来发展趋势进行了分析和展望。Lung cancer has the highest morbidity and mortality among malignant tumors worldwide.The cure rate of lung cancer is high for early diagnosis,thus“early diagnosis and early treatment”has become a consensus.Exhaled gas detection has many advantages including non-invasive detection,convenient sampling and friendly to human body.The biomarkers for early lung cancer might be found through measurement of characteristic metabolites in exhaled gas.Therefore,it is expected to be a simple and effective method of early lung cancer screening,which has attracted lots of attentions.This review summarizes the research progress of early lung cancer screening technology based on detection of exhaled volatile organic compounds(VOCs),including the common clinical screening methods for lung cancer,the exhaled gas components and characteristic VOCs of lung cancer,the collection and pretreatment methods for exhaled VOCs,and the detection techniques for characteristic VOCs of lung cancer.The problems of exhaled gas detection in early lung cancer screening and their future research orientations are also discussed.

关 键 词：呼出气 挥发性有机物 肺癌 早期筛查 评述 

分 类 号：R734.2[医药卫生—肿瘤]