中国鼻咽癌患者抑郁症状发生率的Meta分析  

Prevalence of depressive symptoms in patients with nasopharyngeal carcinoma in China:A meta⁃analysis

作　　者：姜华 吕俭霞 牟文轩 江庆华[2] Jiang Hua;Lv JianXia;Mou Wenxuan;Jiang Qinghua(School of Medicine,University of Electronic Science and Technology of China,Chengdu 610051,China;Sichuan Cancer Hospital and Institute,Cancer Hospital Affiliated to University of Electronic Science and Technology of China,Chengdu 610041,China;School of Nursing,Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]电子科技大学医学院,四川成都610051 [2]四川省肿瘤医院(研究所)电子科技大学附属肿瘤医院,四川成都610041 [3]成都医学院护理学院,四川成都610500

出　　处：《广州医科大学学报》2021年第6期18-25,共8页Academic Journal of Guangzhou Medical University

基　　金：四川省科技厅2020年度社会发展领域重点研发项目(2020YFS0411);四川省科技厅2020年度科技创新创业人才及苗子工程项目(2020JDRC0121)。

摘　　要：目的:系统评价中国鼻咽癌患者抑郁症状发生率。方法:从PubMed、Embase、CINAHL、CBM、中国知网、万方数据库、维普数据库中检索2021年9月前关于鼻咽癌患者抑郁症状发生率的横断面研究,并进行Meta分析。结果:共纳入20篇研究,包含2845例患者,其中发生抑郁1222例。Meta分析结果显示,我国鼻咽癌患者抑郁症状总发生率为54%(95%CI:52%~56%)。亚组分析结果显示抑郁发生率如下:男性41%(95%CI:21%~60%),女性49%(95%CI:26%~71%);50岁以下45%(95%CI:17%~73%),50岁或以上48%(95%CI:33%~62%);治疗前40%(95%CI:28%~54%),低于治疗后的48%(95%CI:37%~61%);南方地区50%(95%CI:44%~54%),高于北方的47%(95%CI:39%~61%);在严重程度上,轻度抑郁发生率29%(95%CI:22%~36%),中度及重度抑郁发生率25%(95CI:13%~38%)。结论:我国鼻咽癌患者抑郁症状发生率较高,中度及重度抑郁发生占比较大,应引起重视。Objective:To systematically review the prevalence of depressive symptoms in patients with nasopharyngeal carcinoma in China.Methods:Literatures were searched by using PubMed,Embase,CINAHL,CBM,CNKI,Wanfang and VIP Database to retrieve cross⁃sectional studies focused on prevalence of depressive symptoms in patients with nasopharyngeal carcinoma in China from inception up to September 2021.Results:A total of 20 studies were included,including 2308 patients,with 1030 having depressive symptoms.The results of Meta analysis showed that the total prevalence of depressive symptoms in Chinese patients with nasopharyngeal carcinoma was 49%(95% CI:34%to 63%).Subgroup analysis showed that the prevalence of depressive symptoms was 41%(95% CI:21%~60%)in men and 49%(95% CI:26%~71%)in women;45%(95%CI:17%~73%)in patients aged below 50 years and 48%in patients aged 50 years or above(95% CI:33%~62%);40% in patients untreated(95% CI:28%~54%),which was lower than 46%in patients after treatment(95% CI:37%~61%);50%in patients from in southern China(95% CI:44%~54%),which was higher than 47% in patients from northern China(95% CI:39%~61%).With regard to severity,the prevalence was 29%(95% CI:22%~36%)for mild depression,and 25%(95%CI:13%~38%)for moderate to severe depression.Conclusion:The prevalence of depressive symptoms in patients with nasopharyngeal carcinoma in China is high and predominated in moderate to severe depression.This situation should call for medical attention.

关 键 词：鼻咽肿瘤 抑郁 发生率 META分析 

分 类 号：R739.6[医药卫生—肿瘤]