代谢相关性脂肪性肝病与代谢综合征的研究  

Study on Metabolic-associated Fatty Liver Disease and Metabolic Syndrome

作　　者：刘英[1] 崔姗姗[1] 暴素青 江霞[1] LIU Ying;CUI Shan-shan;BAO Su-qing;JIANG Xia(Department of Endocrinology,Tianjin First Central Hospital,Tianjin 300192,China)

机构地区：[1]天津市第一中心医院内分泌科,天津300192

出　　处：《医学信息》2022年第1期1-5,共5页Journal of Medical Information

基　　金：国家自然科学基金青年项目(编号:82000763);天津市第一中心医院临床试验科研课题(编号:2017006);天津市第一中心医院科研课题(编号:院CF201818)。

摘　　要：非酒精性脂肪性肝病(NAFLD)是全世界慢性肝病的最常见病因。脂肪肝不仅可与自身免疫性疾病、病毒性肝炎和酒精性肝病等其他肝病并存,还易对疾病的发生发展产生协同作用。随着社会经济的发展,代谢综合征和2型糖尿病患病人数激增,并与其互为因果,共同促进动脉硬化性心脑肾血管疾病和肝外多种恶性肿瘤的发病。2020年代谢相关性脂肪性肝病的新更名,不仅是NAFLD认识史上具有里程碑的事件,也再次证实了代谢相关性脂肪性肝病与代谢综合征及其各组分之间密不可分的相互联系。本文主要就这两种疾病共同的病理生理机制、危险因素及治疗原则做一系统阐述,以期更好的指导临床诊治。Non-alcoholic fatty liver disease(NAFLD)is the most common cause of chronic liver disease worldwide.Fatty liver can not only coexist with other liver diseases such as autoimmune diseases,viral hepatitis and alcoholic liver disease,but also have a synergistic effect on the occurrence and development of diseases.With the development of social economy,the number of patients with metabolic syndrome and type 2 diabetes has surged,and they are mutually causal,jointly promoting the incidence of atherosclerotic cardio-cerebral-renal vascular diseases and multiple extrahepatic malignancies.The new renaming of metabolic fatty liver disease in 2020 is not only a landmark event in the history of NAFLD,but also confirms the inseparable relationship between metabolic fatty liver disease and metabolic syndrome and its components.This article mainly expounds the common pathophysiological mechanism,risk factors and treatment principles of these two diseases,in order to better guide clinical diagnosis and treatment.

关 键 词：非酒精性脂肪性肝病 代谢相关性脂肪性肝病 代谢综合征 糖尿病 肥胖 

分 类 号：R575[医药卫生—消化系统] R589[医药卫生—内科学]