25(OH)D水平与高龄缺血性脑白质病变的关系  

Relationship Between Serum 25(OH)D Level and White Matter Ischemic Lesions in Elderly Patients

作　　者：龚晨[1] 申潇竹[1] 包勤文[1] GONG Chen;SHEN Xiao-zhu;BAO Qin-wen(Department of Geriatrics,Lianyungang Second People's Hospital,Lianyungang 222000,Jiangsu,China)

机构地区：[1]连云港市第二人民医院老年医学科,江苏连云港222000

出　　处：《医学信息》2022年第1期137-139,共3页Journal of Medical Information

基　　金：南京医科大学康达学院科研发展基金项目(编号:KD2019KYJJYB020);连云港市卫生健康委员会科技项目(编号:202024);江苏省“六个一工程”拔尖人才拟资助项目(编号:LGY2019062)。

摘　　要：目的分析高龄缺血性脑白质病变患者血清25-羟基维生素D[25(OH)D]含量和脑白质病变严重程度的关系。方法选取2020年1月-12月连云港市第二人民医院收治的142例高龄缺血性脑白质病变患者,基于ARWMC视觉评定法将评分为1~4分者归入轻度组,5~8分者归入中度组,≥9分者归入重度组,比较三组临床资料,采用有序多分类Logistic回归分析缺血性脑白质病变的危险因素;采用Spearman等级相关分析25(OH)D水平与缺血性脑白质病变严重程度的关系。结果142例高龄缺血性脑白质病变患者中轻度组48例、中度组50例、重度组44例。三组性别、吸烟、高血压、糖尿病、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、尿素、肌酐比较,差异无统计学意义(P>0.05);三组年龄、25(OH)D比较,差异有统计学意义(P<0.05)。有序多分类Logistic回归分析显示,年龄是脑白质病变严重程度的危险因素,25(OH)D是脑白质病变严重程度的保护因素。Spearman相关分析显示,25(OH)D含量与缺血性脑白质病变严重程度呈负相关(P<0.05)。结论25(OH)D水平与高龄缺血性脑白质病变严重程度密切相关,低水平的25(OH)D对中重度缺血性脑白质病变具有一定的预测参考价值。Objective To investigate the relationship between serum 25-hydroxyvitamin D[25(OH)D]level and the severity of white matter ischemic lesions in elderly patients.Methods A total of 142 elderly patients with ischemic cerebral white matter lesions admitted to Lianyungang Second People's Hospital from January to December 2020 were selected.Based on ARWMC visual assessment method,patients with 1-4 scores were classified into mild group,patients with 5-8 scores were classified into moderate group,and patients with≥9 scores were classified into severe group.The clinical data of the three groups were compared,and the risk factors of ischemic cerebral white matter lesions were analyzed by ordered multi-classification Logistic regression.Spearman rank correlation analysis was used to analyze the relationship between 25(OH)D level and the severity of ischemic white matter lesions.Results Among 142 elderly patients with white matter ischemic lesions,48 were in the mild group,50 in the moderate group,and 44 in the severe group.There was no significant difference in gender,smoking,hypertension,diabetes,total cholesterol,triglyceride,high density lipoprotein,low density lipoprotein,urea and creatinine among the three groups(P>0.05).There was significant difference in age and 25(OH)D among the three groups(P<0.05).The ordered multi-classification Logistic regression equation showed that age was a risk factor for the severity of white matter lesions,and 25(OH)D was a protective factor for the severity of white matter lesions.Spearman correlation analysis showed that 25(OH)D content was negatively correlated with the severity of ischemic white matter lesions(P<0.05).Conclusion The level of 25(OH)D is closely related to the severity of ischemic white matter lesions in elderly patients.Low level of 25(OH)D has a certain predictive value for moderate to severe ischemic white matter lesions.

关 键 词：25-羟基维生素D 缺血性脑白质病变 高密度脂蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]