血管源性头晕/眩晕患者脑白质损伤程度与ESSEN评分的关系研究  

CORRELATION BETWEEN SEVERITY OF WHITE MATTER LESIONS AND ESSEN SCORE IN VASCULAR DIZZINESS/VERTIGO PATIENTS

作　　者：姜磊[1] 平荣宇 王淼[1] 李珂[1] 柏秀娟[1] 时霄冰[1] JIANG Lei;PING Rongyu;WANG Miao;LI Ke;BAI Xiujuan;SHI Xiaobing(Department of Neurology,The Second Medical Center&National Clinical Research Center forGeriairic Diseases,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第二医学中心神经内科国家老年疾病临床研究中心,北京市100853

出　　处：《中国煤炭工业医学杂志》2021年第6期572-575,共4页Chinese Journal of Coal Industry Medicine

基　　金：科技部国家重点研发计划项目(编号:2018YFC1312301)。

摘　　要：目的探讨血管源性头晕/眩晕患者脑白质损伤程度与ESSEN评分等临床资料之间的关系。方法以该院收治的52例血管源性头晕/眩晕患者为研究对象,回顾性分析患者的临床资料。根据Fazekas评分结果,将52例患者分为二组,一组为轻度脑白质损伤Fazekas评分≤3分(n=20),另一组为中重度脑白质损伤Fazekas评分≥4分(n=32)。比较二组患者临床资料的差异并进行相关性分析。结果根据脑白质损伤程度分组的二组患者一般资料比较提示,二组患者在年龄、既往脑梗死病史比例、脑梗死二级预防治疗比例、缺血性卒中复发风险ESSEN评分差异有统计学意义(P<0.05)。Spearman相关分析提示脑白质损伤程度与年龄、既往脑梗死病史、脑血管病二级预防治疗及ESSEN评分呈正相关,与肾小球滤过率呈负相关,差异有统计学意义(P<0.05)。结论血管源性头晕/眩晕人群中,高龄、卒中病史、ESSEN评分及肾小球滤过率降低是脑白质损伤的危险因素。Objective To explore the correlation between severity of white matter lesions and the Essen score in patients with vascular dizziness/vertigo.Methods The clinical data of fifty-two patients with vascular dizziness/vertigo in Chinese PLA General Hospital were analyzed retrospectively.According to the results of Fazekas score, 52 patients were divided into two groups.One group was mild white matter lesions with Fazekas score≤3(n=20),and the other group was moderate and severe white matter lesions with Fazekas score≥4(n=32).The differences of clinical data between the two groups were compared and analyzed.Results The comparison of the general data of the two groups grouped according to the severity of white matter Lesions showed that there were significant differences between the two groups in age, the proportion of previous cerebral infarction history, the proportion of secondary prevention and treatment of cerebral infarction, and the Essen score(P<0.05).Spearman correlation analysis showed that the severity of white matter Lesions was positively correlated with age, previous history of cerebral infarction, secondary prevention and treatment of cerebrovascular disease and Essen score, and negatively correlated with glomerular filtration rate,the difference was statistically significant(P<0.05).Conclusion Among the vascular dizziness/vertigo patients, old age, stroke history, Essen score and decreased glomerular filtration rate are the risk factors of white matter lesions.

关 键 词：头晕 眩晕 脑白质病变 卒中 ESSEN评分 

分 类 号：R741[医药卫生—神经病学与精神病学]