圆锥角膜患者角膜光密度与形态及生物力学的相关性研究  

Correlation among corneal densitometry,corneal topographic,and biomechanical properties in keratoconus

作　　者：李彩红[1] 赵宏[1] 邹鹏飞 Cai-Hong Li;Hong Zhao;Peng-Fei Zou(Department of Ophthalmology, Zhengzhou Second People's Hospital, Zhengzhou Eye Institute, Zhengzhou 450006, Henan Province, China)

机构地区：[1]中国河南省郑州市第二人民医院眼科郑州市眼科研究所,450006

出　　处：《国际眼科杂志》2022年第2期309-313,共5页International Eye Science

基　　金：河南省科技攻关项目(No.182102310459)。

摘　　要：目的:探讨圆锥角膜患者角膜光密度与角膜形态参数及生物力学特性的相关性。方法:回顾性病例研究。收集2020-01/12在郑州市第二人民医院就诊的原发性圆锥角膜患者48例70眼,使用Pentacam眼前段分析系统测量角膜形态,包括角膜前表面中央扁平子午线曲率(K1)、角膜前表面陡峭子午线曲率(K2)、角膜前表面中央平均曲率(Km)、角膜前表面最大曲率(Kmax)、角膜前表面高度(ACE)、角膜后表面高度(PCE)、最薄点角膜厚度(TCT),以及圆锥锥顶距角膜顶点的距离(DCA)。测量不同分区不同层次的角膜光密度。使用可视化角膜生物力学测量仪观察角膜形变过程并测量相关参数,包括第一次压平时间(AT1),第一次压平长度(AL1),第一次压平速度(V1),第二次压平时间(AT2),第二次压平长度(AL2),第二次压平速度(V2),最大压陷时间(HCT),最大压陷形变幅度(HCDA),最大压陷曲率半径(HCR),最大压陷峰距(HCPD),硬度参数(SPA1),水平方向Ambrósio相关厚度(ARTh)。结果:圆锥角膜患者距角膜顶点≤2mm前层光密度与K1、K2、Km、Kmax均呈正相关(r=0.291、0.315、0.315、0.387;P=0.015、0.008、0.008、0.001)。距角膜顶点≤2mm、>2mm且≤6mm前层及全层、>2mm且≤6mm后层光密度与ACE均呈正相关(r=0.465、0.302、0.317、0.291、0.335;P<0.01、P=0.011、0.008、0.014、0.005);上述各区域各层的光密度与PCE均呈正相关(r=0.565、0.369、0.348、0.306、0.284;P<0.01、P=0.002、0.003、0.010、0.017)。距角膜顶点≤2mm前、中、后及全层光密度,>2mm且≤6mm中、后及全层光密度均与AL1均呈负相关(r=-0.284、-0.290、-0.245、-0.326、-0.282、-0.395、-0.310;P=0.017、0.015、0.041、0.006、0.018、0.001、0.009)。距角膜顶点≤2mm中层光密度、>2mm且≤6mm中、后层光密度与AL2呈负相关(r=-0.246、-0.256、-0.256;P=0.041、0.032、0.032)。距角膜顶点≤2mm前层光密度与HCR呈负相关(r=-0.308,P=0.010)。距角膜顶点≤2mm中、AIM:To investigate the correlation among corneal densitometry,corneal topographic parameters,and corneal biomechanical properties in keratoconus.METHODS:Retrospective case study.A total of 70 eyes of 48 keratoconus patients were enrolled in this study.Corneal topography were measured using Pentacam,inclding the flat keratometry of anterior cornea(K1),the steep keratometry of anterior cornea(K2),the mean keratometry of anterior cornea(Km),the maximum keratometry of anterior cornea(Kmax),anterior corneal elevation(ACE),posterior corneal elevation(PCE),thinnest corneal thickness(TCT),and the distance from cone to apex(DCA).Corneal optical density of different corneal layers and zones were measured with the Scheimpflug-based Pentacam corneal densitometry module.Corneal biomechanical properties were measured using CorVis ST,inclding time of the first applanation(AT1),length of the first applanation(AL1),velocity of the first applanation(V1),time of the second applanation(AT2),length of the second applanation(AL2),velocity of the second applanation(V2),the highest concavity time(HCT),the highest concavity deformation amplitude(HCDA),the highest concavity radius(HCR),the highest concavity peak distance(HCPD),stiffness parameter applanation 1(SPA1),Ambrósio’s relational thickness horizontal(ARTh).RESULTS:Correlation between corneal densitometry and topographic parameters:The corneal densitometry values of the anterior≤2mm layer correlated with the K1,K2,Km and Kmax values positively(r=0.291,0.315,0.315,0.387;P=0.015,0.008,0.008,0.001).The corneal densitometry values of the anterior≤2mm,anterior>2 and≤6mm,total≤2mm,total>2 and≤6mm,and posterior>2 and≤6mm layers correlated with the anterior corneal elevation positively(r=0.465,0.302,0.317,0.291,0.335;P<0.01,P=0.011,0.008,0.014,0.005),and also with the posterior corneal elevation(r=0.565,0.369,0.348,0.306,0.284;P<0.01,P=0.002,0.003,0.010,0.017).Correlation between corneal densitometry and biomechanical properties:the corneal densitometry values of all≤2mm,c

关 键 词：圆锥角膜 光密度 角膜地形图 生物力学 

分 类 号：G63[文化科学—教育学]