DNA双链断裂修复相关基因XRCC1、XRCC3、TP53、Rad51多态性与结直肠癌易感性关联的Meta分析  

Polymorphisms in DNA double-strand break repair genes XRCC1,XRCC3,TP53,and Rad51 and risk of colorectal cancer:a meta-analysis

作　　者：苟怡凡 周思佳 张永吉 宁宁 康思涵 逯晓波 GOU Yifan;ZHOU Sijia;ZHANG Yongji;NING Ning;KANG Sihan;LU Xiaobo(Department of Hygienic Toxicology,School of Public Health,China Medical University,Shenyang 110122,China)

机构地区：[1]中国医科大学公共卫生学院卫生毒理学教研室,辽宁沈阳110122

出　　处：《沈阳医学院学报》2022年第1期15-22,共8页Journal of Shenyang Medical College

基　　金：“中国医科大学大学生创新创业训练计划”资助项目(No.202010159026);国家自然科学基金项目(No.81773470)。

摘　　要：目的:探究4种DNA修复基因的单核苷酸多态性(XRCC1 Arg399Gln、XRCC3 Thr241Met、TP53 Arg72Pro和Rad51135 G>C)与结直肠癌(colorectal cancer,CRC)发病风险的关联。方法:在数据库检索有关基因XRCC1、XRCC3、TP53、Rad51多态性与CRC易感性关联的文献,筛选出符合条件的文献,应用Review Manager 5.3和Stata 16.0对各项研究进行统计分析(异质性检验和Meta分析、敏感性分析和发表偏倚评估)。结果:纳入11项关于XRCC1的研究(2448例病例,3681例对照);15项关于XRCC3的研究(6150例病例,7773例对照);8项关于TP53的研究(3970例病例,4024例对照);6项关于Rad51的研究(853例病例,800例对照)。显性模型结果显示XRCC1 Arg399Gln、XRCC3 Thr241Met、TP53 Arg72Pro、Rad51135G>C与CRC发病风险无明显相关性(XRCC1:OR=0.98,95%CI:0.72~1.34;XRCC3:OR=1.20,95%CI:0.97~1.49;TP53:OR=1.08,95%CI:0.99~1.18;Rad51:OR=0.98,95%CI:0.46~2.11)。结论:XRCC1 Arg399Gln、XRCC3 Thr241Met、TP53 Arg72Pro、Rad51135G>C基因多态性与CRC易感性之间无明显相关性。Objective:To investigate the relationship between the single nucleotide polymorphisms(SNPs)of four DNA damage repair genes(XRCC1 Arg399Gln,XRCC3 Thr241Met,TP53 Arg72Pro and Rad51135G>C)and the risk of colorectal cancer(CRC).Methods:The public databases were searched for articles related to XRCC1,XRCC3,TP53 and Rad51 polymorphisms and CRC susceptibility,and the eligible articles were screened.The Review Manager 5.3 and Stata 16.0 were used for statistical analysis(heterogeneity test and meta-analysis,sensitivity analysis and publication bias assessment).Results:A total of 11 studies on XRCC1(2448 cases,3681 controls),15 studies on XRCC3(6150 cases,7773 controls),8 studies on TP53(3970 cases,4024 controls),and 6 studies on Rad51(853 cases,800 controls)were included.The results showed that XRCC1 Arg399Gln,XRCC3 Thr241Met,TP53 Arg72Pro and Rad51135 G>C were not significantly associated with the risk of CRC in the dominant genetic model(XRCC1:OR=0.98,95%CI:0.72-1.34;XRCC3:OR=1.20,95%CI:0.97-1.49;TP53:OR=1.08,95%CI:0.99-1.18;Rad51:OR=0.98,95%CI:0.46-2.11).Conclusion:There is no relationship between polymorphisms of XRCC1 Arg399Gln,XRCC3 Thr241Met,TP53 Arg72Pro,Rad51135G>C and susceptibility to CRC.

关 键 词：DNA修复基因 单核苷酸多态性 结直肠癌 发病风险 META分析 

分 类 号：R735.3[医药卫生—肿瘤]