基于网络药理学探究黄酮对2型糖尿病的作用机制  

Exploring the mechanism of flavonoids on type 2 diabetes mellitus based on network pharmacology

作　　者：席晓萌 姜云鸽 王煜丹 黄相中[1,2] 田凯[1,2] XI Xiao-meng;JIANG Yun-ge;WANG Yu-dan;HUANG Xiang-zhong;TIAN Kai(Laboratory of Theoretical and Computational Chemistry,Yunnan Minzu University,Kunming 650500,China;Key Laboratory of Chemistry in Ethnic Medicinal Resources,State Ethnic Affairs Commission and Ministry of Education of China,Yunnan Minzu University,Kunming 650500,China)

机构地区：[1]云南民族大学理论与计算化学实验室,云南昆明650500 [2]云南民族大学民族药资源化学国家民族事务委员会-教育部重点实验室,云南昆明650500

出　　处：《云南民族大学学报（自然科学版）》2022年第1期15-23,34,共10页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：国家自然科学基金(81960783);云南省高校传统彝药药效物质基础研究科技创新团队项目.

摘　　要：应用网络药理学的方法探究了已分离得到的6个黄酮与2型糖尿病相互作用的机制.通过相关数据库的筛选与预测,获得了化合物与疾病的靶基因,进一步得到了两者的交集基因;通过Cytoscape 3.8.0软件构建了这些化合物与2型糖尿病相关的PPI网络与成分-疾病-靶点网络图;通过R语言半编程程序对交集基因进行生物功能富集和通路富集分析,明确了6个黄酮类化合物是通过多靶点、多通路治疗2型糖尿病的作用机制.In this paper,the interaction mechanisms of six flavonoids separation in the laboratory and type 2 diabetes mellitus were explored by using the method of network pharmacology.Through the screening and prediction of relevant databases,the target genes of compounds and diseases are obtained,and the intersection genes of the two are further obtained;The PPI networks and component-disease-target networks of these compounds related to type 2 diabetes mellitus were constructed by Cytoscape 3.8.0 software.The biological function enrichment and pathway enrichment analysis of the intersecting genes were performed by R language semi-programming program,and the action mechanisms of six flavonoids in the treatment of type 2 diabetes mellitus by multi-target and multi-pathway were identified.

关 键 词：黄酮 2型糖尿病 网络药理学 PPI网络 富集分析 

分 类 号：R914.2[医药卫生—药物化学]