度洛西汀与帕罗西汀对老年抑郁症患者主观睡眠质量的作用研究  

Study on the Effect of Duloxetine and Paxil on Subjective Sleep Quality in Elderly Patients with Depression

作　　者：张特 Zhang Te(Harbin First Specialized Hospital, Harbin 150000, China)

机构地区：[1]哈尔滨市第一专科医院,哈尔滨150000

出　　处：《黑龙江科学》2022年第2期84-85,共2页Heilongjiang Science

摘　　要：探讨度洛西汀与帕罗西汀对老年抑郁症患者主观睡眠质量的影响。选择我院收治的65例老年抑郁症患者,随机分为帕罗组和度洛组,对比两组治疗后抑郁与焦虑症状改善效果,并评估两组主观睡眠质量及不良反应。度洛组治疗4周后(16.87±3.08分)、治疗3个月后PSQI评分(18.47±2.17分)显著高于帕罗组(14.05±2.98分、15.18±3.89分)(P<0.05)。两药均可有效缓解老年抑郁症患者的焦虑及抑郁症状,且安全性无显著差异,但度洛西汀改善患者睡眠质量的效果显著好于帕罗西汀。The study explores the effect duloxetine and paxil on subjective sleep quality in elderly patients with depression.65 depressed elderly in the hospital are selected,and they are divided into paxil group and duloxetine group randomly.Improvement effect of depression and anxiety symptom of two groups are compared,and subjectivity sleep quality and adverse reaction of two groups are evaluated.PSQI score of duloxetine group after four weeks and 3 months are(16.87±3.08)and(18.47±2.17),which are significant better than(14.05±2.98)and(15.18±3.89)in paxil group(P<0.05).Anxiety and depression symptom of two groups can be effectively relieved.It is safe,with no significant difference.The effect of duloxetine on the improvement of patient sleep quality is better than that of paxil.

关 键 词：度洛西汀 帕罗西汀 老年 抑郁症 主观睡眠质量 疗效 

分 类 号：R749.4[医药卫生—神经病学与精神病学]