肿瘤进化异质性研究现状及进展  

Research status and progress on tumor evolutionary heterogeneity

作　　者：曹勇[1] 于大海[2] CAO Yong;YU Dahai(College & Hospital of Stomatology,Guangxi Medical University,Guangxi Nanning 530021,China;Department of Stomatology,the First Affiliated Hospital of Guangxi Medical University,Guangxi Nanning 530021,China)

机构地区：[1]广西医科大学口腔医学院/附属口腔医院,广西南宁530021 [2]广西医科大学第一附属医院口腔科,广西南宁530021

出　　处：《现代肿瘤医学》2022年第2期331-334,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81360407);广西自然科学基金(编号:2018GXNSFAA050088)。

摘　　要：肿瘤进化是肿瘤异质性、肿瘤转移及药物靶向治疗的研究基础。近年来,肿瘤原发灶与转移灶进化关系的研究取得快速进展。肿瘤进化研究涉及基因组学、转录组学、表观遗传学等多种组学研究方法,通过不同的研究方法构建了多种肿瘤进化模型。本文通过文献回顾,对肿瘤进化的基因组学基础、肿瘤进化的基因组学研究方法及肿瘤进化的不同模式的研究现状及进展进行综述,并对肿瘤进化研究的新方法进行展望。Tumor evolution is the research basis for tumor heterogeneity,tumor metastasis,and drug-targeted therapy.In recent years,rapid progress has been made in the study of the evolutionary relationship between primary tumors and metastases.Tumor evolution research involves a variety of omics research methods such as genomics,transcriptomics,epigenetics,and various tumor evolution models have been constructed through different research methods.This article reviews the literature and attempts to review the research status and progress of the genomics basis of tumor evolution,the genomics research methods of tumor evolution,the different models of tumor evolution,and to prospect for new methods of tumor evolution research.

关 键 词：肿瘤进化 肿瘤异质性 基因组学 分支进化 

分 类 号：R730.231[医药卫生—肿瘤]