肿瘤光热治疗引发的免疫效应及光热转换剂在其中的作用  

Recent research on immune effect induced by tumor photothermal therapyand the function of photothermal conversion agents in it

作　　者：姜珊 刘钊[1] 程文[1] JIANG Shan;LIU Zhao;CHENG Wen(Department of Ultrasound,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150008,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院超声科,黑龙江哈尔滨150008

出　　处：《现代肿瘤医学》2022年第1期143-149,共7页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:8187070804,81873900);黑龙江省卫生健康委科研课题(编号:2019052);哈尔滨医科大学创新科学研究资助项目(编号:2020-KYYWF-1471)。

摘　　要：如今,利用光热转化剂(photothermal conversion agents,PTA)在近红外光(near-infrared,NIR)照射下产生足够热量来消融肿瘤的光热疗法(photothermal therapy,PTT)引起了广泛的研究关注。PTT相比于传统的常规肿瘤治疗方法(例如手术、化疗、放疗等),是一种新兴的、有潜力的治疗手段,因为它具有微创、精准性高、毒副反应小等优势。PTT是PTA吸收光能并将其转化为热能,产生局部高热杀死靶细胞的过程。PTA作为其中重要的媒介在治疗中起着举足轻重的作用。研究发现PTA在NIR的作用下不仅显示对癌细胞的细胞毒性,并且可以引起相应的免疫应答,有潜在的免疫治疗作用。近几年来,很多研究尝试开发新型PTA以改善PTT的特异性疗效,实现PTT与免疫治疗的协同。在本综述中,我们主要阐述PTT引起的免疫机制,并以具有代表性的PTA说明其在免疫效应中发挥的作用以及与协同免疫治疗的应用。Nowadays,photothermal therapy(PTT),which uses photothermal conversion agents(PTA)to produce enough heat to ablate tumors under near-infrared(NIR)light,has attracted widespread research attention.Compared with traditional tumor treatment models such as surgery,chemotherapy and radiotherapy,PTT has a certain suction force because it has certain advantages,including minimally invasive,reduced side effects and high accuracy.Photothermal therapy is a process in which PTA absorb light energy and convert it into heat energy,producing local high heat to kill target cells.PTA,as an important medium in PTT,plays an important role in treatment.The study found that PTA not only show cytotoxicity to cancer cells under the action of NIR,but also cause corresponding immune response stimulation,which has the potentially important role of immunotherapy.In recent years,many studies have attempted to develop new PTA to improve the therapeutic specificity of PTT.In this review,we focus on the molecular mechanisms of immunology caused by PTT,and we will explain the role of PTA in immune effects with representative PTA and the application of synergized immunotherapy.

关 键 词：光热治疗 光热转化剂 免疫分子机制 免疫治疗 

分 类 号：R730.5[医药卫生—肿瘤]