体外HPV感染皮肤粘膜细胞及器官模型的研究进展  

Advances in the research of HPV-infected skin mucosal cell models in vitro

作　　者：唐奕 陈荃[2] 彭丽倩[2] 陈教全 李华平[2] 朱慧兰[2] TANG Yi;CHEN Quan;PENG Liqian;CHEN Jiaoquan;LI Huaping;ZHU Huilan(Guangzhou Medical University,Guangzhou 511436,China;Guangzhou Institute of Dermatology,Guangzhou 510095,China)

机构地区：[1]广州医科大学,广东广州511436 [2]广州市皮肤病防治所,广东广州510095

出　　处：《皮肤性病诊疗学杂志》2021年第6期520-523,共4页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：广东省医学科学技术研究基金(A2019025,A2017082);广州市科技计划项目(201804010058);广州市医药卫生科技计划项目(20171A011282,20181A011058)。

摘　　要：人乳头瘤病毒(HPV)感染与多种疾病相关,特别是高危型人HPV与生殖器肿瘤、皮肤肿瘤等发生发展存在关联。HPV阳性的肿瘤细胞系是较早研究HPV特性的体外细胞模型,特别是致癌特性。近年来,体外感染皮肤粘膜细胞系的出现推动HPV感染体外细胞模型的研究进程,但由于HPV的种属特异性以及复制和增殖对上皮细胞分化的依赖性,目前不能在常规的细胞培养中产生完整的感染过程。器官型培养模型的出现和发展可以模拟HPV病毒在皮肤粘膜的感染过程,是更好的研究HPV感染和治疗药物的模型。本文对目前体外HPV感染皮肤粘膜细胞及器官模型的研究进展进行综述。Human papillomavirus(HPV) infection is associated with a range of diseases. In particular, high-risk HPV is a main pathogenic factor of the promotion and development of genital tumors and skin tumors. HPV-positive cell lines are in vitro cell models for early study of HPV characteristics, especially oncogenic characteristics. Although the emergence of in vitro infected skin mucosal cell lines has promoted the research process of HPV infected in vitro cell models in recent years, the full infectious life cycle cannot be established in cell culture at present since HPV’s special biological characteristics and the dependence of replication and proliferation on epithelial differentiation. Hence, the occurrence and development of organotypic culture models can simulate the infection process of HPV virus in mucosa in order to provide better models for researching HPV infection and therapeutic drugs. In this paper, the progress of HPV infected skin mucosal cell models are reviewed.

关 键 词：人乳头瘤病毒 体外培养 细胞培养 器官型培养 

分 类 号：R737.33[医药卫生—肿瘤] R-33[医药卫生—临床医学]