动态适形弧放射治疗与容积旋转调强放射治疗在非小细胞肺癌立体定向放射治疗中的剂量学差异  

Dosimetric Comparison of Dynamic Conformal Arc Therapy Versus Volumetric Modulated Arc Therapy in Stereotactic Body Radiotherapy for Non-Small Cell Lung Cancer

作　　者：魏鹏 叶书成[1] 刘卫东 杨君东[1] 王梦雅 吕敏 王丽芳[1] Wei Peng;Ye Shucheng;Liu Weidong;Yang Jundong;Wang Mengya;Lv Min;Wang Lifang(Department of Oncology,Affiliated Hospital of Jining Medical University,Jining Shandong 272000,China;Medical College Jining Medical University,Jining Shandong 272067,China)

机构地区：[1]济宁医学院附属医院肿瘤科,山东济宁272000 [2]济宁医学院临床医学院,山东济宁272067

出　　处：《医疗装备》2022年第1期1-4,共4页Medical Equipment

基　　金：济宁医学院附属医院“苗圃”科研计划项目(MPMS-2019-019);中华国际医学交流基金会肿瘤精准放疗星火计划临床科研基金(2019-N-11-22)。

摘　　要：目的比较动态适形弧放射治疗(DCAT)与容积旋转调强放射治疗(VMAT)在非小细胞肺癌立体定向放射治疗(SBRT)中的剂量学差异。方法选取2016年1月至2020年1月于济宁医学院附属医院接受放射治疗的15例非小细胞肺癌患者,用Monaco5.11.03治疗计划系统以相同的目标优化模板和治疗计划参数分别设计DCAT计划与VMAT计划,在靶区剂量覆盖率均为95%的情况下比较两组计划的计划靶区(PTV)和危及器官剂量分布、计算时间、机器跳数、控制点数和出束时间等指标。结果DCAT计划与VMAT计划均符合PTV和危及器官的临床要求。VMAT计划的一些危及器官剂量低于DCAT计划,而且R_(50%)优于DCAT计划;但DCAT计划的计算时间、出束时间均短于VMAT计划,机器跳数、控制点数均低于VMAT计划;DCAT计划的机器跳数比VMAT计划平均少1322.1 MU。结论对非小细胞肺癌患者采用DCAT和VMAT两种技术进行SBRT,均能获得比较满意的靶区剂量分布,VMAT计划对于危及器官的保护更好,DCAT计划在计算时间、机器跳数、控制点数和出束时间方面更具优势。Objective The dosimetric difference of dynamic conformal arc therapy(DCAT)versus volumetric modulated arc therapy(VMAT)in stereotactic body radiotherapy(SBRT)for non-small cell lung cancer was compared.Methods 15 patients who diagnosed with non-small cell lung cancer and received radiotherapy in Affiliated Hospital of Jining Medical University were selected.The DCAT plan and VMAT plan were designed for each patients respectively with the Monaco 5.11.03 treatment planning system under the same conditions,that is,the same objective constraint template and treatment planning parameters.When 95%of the target volume reached the prescribed dose for the two plans,the dosimetric distribution of plan target volume(PTV)and organs at risk,calculation time,monitor unit,control points and spill time were compared between them.Results Both DCAT plan and VMAT plan could meet the clinical requirements of PTV and organs at risk.The doses of some organs at risk of the VMAT plan were lower than those of the DCAT plan,meanwhile R_(50%) was superior to the DCAT plan;While the calculation time and spill time of the DCAT plan were both shorter than those of the VMAT plan,and the monitor unit and control points were both lower than those of the VMAT plan;The monitor unit of the DCAT plan was 1322.1 MU lower than that of the VMAT plan.Conclusions Non-small cell lung cancer patients treated with SBRT through DCAT and VMAT can both obtain the satisfactory dose distribution in the target area.VMAT plans showed better in protecting organs at risk.However,DCAT plans have advantages in terms of calculation time,monitor time,control points and spill time.

关 键 词：非小细胞肺癌 立体定向放射治疗 容积旋转调强放射治疗 动态适形弧放射治疗 剂量学 

分 类 号：R734.2[医药卫生—肿瘤]