S100A12/RAGE/NF-κB炎性信号通路与急性脑梗死严重程度的相关性  

Correlation between S100A12/RAGE/NF-kB inflammatory signal pathway and severity of acute cerebral infarction

作　　者：解渊 苑瑞敏 张晗 袁超 储佺兵 XIE Yuan;YUAN Rui-min;ZHANG Han;YUAN Chao;CHU Quan-bing(Department of Neurology,Ma′anshan Shiqiye Hospital,Ma′anshan Anhui 243000,China)

机构地区：[1]马鞍山十七冶医院神经内科,安徽马鞍山243000

出　　处：《蚌埠医学院学报》2022年第1期41-43,46,共4页Journal of Bengbu Medical College

基　　金：安徽省马鞍山市科技局项目(马科201769号)。

摘　　要：目的:观察急性脑梗死病人血清中S100钙结合蛋白A12(S100A12)、晚期糖基化终产物受体(RAGE)及核转录因子-κB(NF-κB)的动态变化,并分析其与脑梗死严重程度的相关性。方法:纳入82例急性脑梗死病人为观察组,于入院后1、3、7 d进行美国国立卫生研究院卒中量表(NIHSS)评分,ELISA检测相应时间点血清S100 A12、RAGE及NF-κB水平变化,并与NIHSS评分进行相关性分析;另纳入85例因非脑血管病住院病人为对照组,于入院后1 d检测S100 A12、RAGE及NF-κB水平。结果:观察组1、3、7 d血清S100 A12、RAGE及NF-κB水平均明显高于对照组(P<0.01);1 d血清S100 A12、RAGE以及NF-κB水平均最高(P<0.05~P<0.01);3 d与7 d水平差异均无统计学意义(P>0.05)。相关性分析显示,各时间点血清S100 A12、RAGE及NF-κB水平与相应NIHSS评分均呈正相关关系(P<0.05~P<0.01)。结论:脑梗死急性期S100 A12、RAGE及NF-κB水平升高,且与急性脑梗死后神经功能缺损严重程度相关。Objective:To observe the dynamic changes of S100 calcium binding protein A12(S100A12),receptor for advanced glycation end products(RAGE)and nuclear factorκB(NF-κB)in patients with acute cerebral infarction,and analyze the correlation between them and severity of cerebral infarction.Methods:Eighty-two patients with acute cerebral infarction were set as the observation group.On the 1 d,3 d and 7 d after admission,the NIHSS scores in the observation group were evaluated,the serum levels of S100A12,RAGE and NF-κB were detected using ELISA,and the correlation between the above indexes and NIHSS score was analyzed.Eighty-five patients without cerebrovascular disease were set as the control group,and the serum levels of S100A12,RAGE,NF-κB were detected on the first day after admission.Results:The serum levels of S100A12,RAGE and NF-κB in observation group on the 1 d,3 d and 7 d were significantly higher than those in control group(P<0.01).The levels of S100A12,RAGE and NF-κB was highest on the 1 d(P<0.05 to P<0.01),and tbe differences of which between 3 d and 7 d were not statistically significant(P>0.05).The results of correlation analysis indicated that the serum levels of S100A12,RAGE and NF-κB were positively correlated with NIHSS score at each time point(P<0.05 to P<0.01).Conclusions:The levels of S100A12,RAGE and NF-κB increase,which are related to the severity degree of neurological deficit in patients with acute cerebral infarction.

关 键 词：脑梗死 S100钙结合蛋白A12 晚期糖基化终产物受体 核转录因子-ΚB 

分 类 号：R743.3[医药卫生—神经病学与精神病学]