局部放疗联合二氯化锶-89治疗肺癌多发骨转移患者的效果  

Effects of local radiotherapy combined with ^(89)SrCl_(2) in treatment of patients with multiple bone metastases of lung cancer

作　　者：张玲 李静静[1] 张勇[1] ZHANG Ling;LI Jingjing;ZHANG Yong(Department of Nuclear Medicine of the Third People’s Hospital of Zhengzhou,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州市第三人民医院核医学科,河南郑州450000

出　　处：《中国民康医学》2022年第1期31-33,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察局部放疗联合二氯化锶-89(^(89)SrCl_(2))治疗肺癌多发骨转移患者的效果。方法:回顾性分析2018年10月至2020年10月该院收治的70例肺癌多发骨转移患者的临床资料,按照治疗方式不同分为对照组和观察组各35例。对照组给予^(89)SrCl_(2)治疗,观察组在对照组基础上采用局部放疗。比较两组骨转移病灶疗效,治疗前后骨痛程度[视觉模拟评分法(VAS)评分]、生命质量[Karnofsky功能状态(KPS)评分]、骨转移病灶数量和不良反应发生率。结果:观察组骨转移病灶治疗总有效率为94.29%(33/35),高于对照组的62.86%(22/35),差异有统计学意义(P<0.05);治疗后,观察组VAS评分低于对照组,KPS评分高于对照组,骨转移病灶数量少于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:局部放疗联合^(89)SrCl_(2)治疗肺癌多发骨转移患者,可提高治疗总有效率和KPS评分,降低VAS评分,以及减少骨转移病灶数量,效果优于单纯^(89)SrCl_(2)治疗。Objective:To observe effects of local radiotherapy combined with ^(89)SrCl_(2) in treatment of patients with multiple bone metastases of lung cancer.Methods:A retrospective analysis of the clinical data of 70 patients with multiple bone metastases of lung cancer admitted to the hospital from October 2018 to October 2020 was performed.They were divided into control group and observation group according to different treatment methods,35 cases in each.The control group was treated with ^(89)SrCl_(2),while the observation group was treated with local radiotherapy on the basis of that of the control group.The curative effects of bone metastases,the degree of bone pain[visual analogue scale(VAS)score],the quality of life[Karnofsky functional status score(KPS)score],the number of bone metastases,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of bone metastases in the observation group was 94.29%(33/35),which was higher than 62.86%(22/35)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the VAS score of the observation group was lower than that of the control group;the KPS score was higher than that of the control group;the number of bone metastases was less than that of the control group;and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Local radiotherapy combined with ^(89)SrCl_(2) in the treatment of the lung cancer patients with multiple bone metastases can improve the total effective rate of treatment and the KPS score,reduce the VAS score,and reduce the number of bone metastases.Moreover,it is superior to single ^(89)SrCl_(2) treatment.

关 键 词：二氯化锶-89 局部放疗 肺癌多发骨转移 骨痛 生命质量 骨转移病灶 不良反应 

分 类 号：R730.5[医药卫生—肿瘤]