伏邪“结”病机与幽门螺旋杆菌免疫逃逸机制探微  

Discussion on the"Jie"Pathogenesis of Fuxie and the Immune Escape Mechanism of Helicobacter Pylori

作　　者：梁绮婷[1] 罗敏怡 李嘉丽 杨鹏辉 马兴发 贺生才 潘华山 LIANG Qi-ting;LUO Min-yi;LI Jia-li;YANG Peng-hui;MA Xing-fa;HE Sheng-cai;PAN Hua-shan(Guangzhou University of Chinese Medicine,Guangzhou,510006,China;Guangdong Food and Drug Voca-tional College,Guangzhou,510520,China)

机构地区：[1]广州中医药大学,广东广州510006 [2]广东食品药品职业学院,广东广州510520

出　　处：《时珍国医国药》2021年第12期2962-2964,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(81973816);广东省自然科学基金(2019A1515010822);广东省普通高校特色创新类项目(2020KTSCX256)。

摘　　要：幽门螺旋杆菌感染是一种慢性感染引起的相关疾病是各种免疫细胞和化学物质长期作用的结果,加之幽门螺旋杆菌自身酶的作用和基因多样性,导致其可在体内持续定植存活,逃避宿主免疫系统。中医理论中的伏邪"结"病机指邪气伏于内,并与机体胶着难解的病理状态,是邪气伏留、病情迁延的重要原因,这与幽门螺旋杆菌持续定植引起感染甚或致癌的免疫逃逸机制有一定相关性。文章基于伏邪"结"病机理论,从基本概念、病机特点、治疗思路着手,结合幽门螺旋杆菌免疫逃逸机制的现代研究进展,分析两者之间的关联,以期为中医药防治幽门螺旋杆菌提供新思路。Helicobacter pylori(HP)infection is a chronic infection,and its related diseases are the result of the long-term effects of various immune cells and chemicals,together with the role of Hp’s own enzymes and gene diversity,resulting in its continued colonization and survival avoiding the host immune system.The pathogenesis of"Jie"refers to the pathological state in which pathogenic factors are trapped and stuck inside,which is an important reason for the retention of pathogenic factors and the delay of the disease.It’s related to the immune escape mechanism caused by the continuous colonization of Hp to cause infection or even cancer.This paper based on the"Jie"pathogenesis of fuxie,starting from the basic concept,pathogenesis characteristics and treatment ideas,combined with the modern research progress of the immune escape mechanism of Hp,so as to provide new ideas for the prevention and treatment of Hp with traditional Chinese medicine.

关 键 词：伏邪 “结”病机 幽门螺旋杆菌 免疫逃逸 治疗 

分 类 号：R228[医药卫生—中医基础理论]