Compatibility studies of the Thiocolchicoside with Eudragit RLPO,Eudragit E100 and Eudragit L100 using thermal and non-thermal methods  

作　　者：Nishant Thakur Bhupinder Kaur Manish Goswami Chandan Sharma 

机构地区：[1]University Institute of Pharma Sciences,Chandigarh University,Gharuan,Mohali,Punjab,140413,India [2]Saraswati College of Pharmacy,Gharuan,Mohali,Punjab,140413,India

出　　处：《Drug Combination Therapy》2022年第1期1-9,共9页药物联合治疗

基　　金：This work was carried out under the financial support received from Ministry of Science&Technology,Department of Science and Technology New Delhi,Govt of India(File No SP/YO/063).

摘　　要：Aim:Thiocolchicoside is a sulfur derivative of the colchicine widely used as the skeletal muscle relaxant in variety of muscle related disorders.Compatibility of the Thiocolchicoside is screened with the Eudragit RLPO,Eudragit L-100 and Eudragit E-100 for checking its suitability for formulating as transdermal drug delivery system.Methods:The binary mixtures of the drug and polymers were placed in the Petri plates and the temperature and humidity were adjusted at 40℃±2℃ and 75%relative humidity.The drug and polymer mixture were examined on the FTIR and DSC for detection of any possible physical and chemical interactions.Results:Eudragit E100 and L100showed no significant interaction with the Thiocolchicoside and that was justified with differential scanning calorimetryand Fourier transform infraredspectra.However,Eudragit RLPO showed a slight interaction with the drug during the compatibility studies.

关 键 词：Thiocolchicoside Relative humidity EUDRAGIT Compatibility Fourier transform infrared Differential scanning calorimetry 

分 类 号：R94[医药卫生—药剂学]