红细胞寿命在肿瘤相关性贫血诊断中的特点及临床应用  

Characteristics and clinical application of erythrocyte life in diagnosis of tumor associated anemia

作　　者：梁立莉 赵迎喜 黄丹[2] 熊春[2] 谢淑琼 罗香妮 LIANG Lili;ZHAO Yingxi;HUANG Dan;XIONG Chun;XIE Shuqiong;LUO Xiangni(Third Wards,Department of Oncology,Second Affiliated Hospital of Guangxi University of Science and Technology,Nanning,Guangxi 545005,China;Department of Oncology and Hematology,First Affiliated Hospital of Guangxi University of Sience and Technology,Nanning,Guangxi 545002,China)

机构地区：[1]广西科技大学第二附属医院肿瘤内科三病区,南宁545005 [2]广西科技大学第一附属医院肿瘤血液内科,南宁545002

出　　处：《重庆医学》2022年第2期264-266,270,共4页Chongqing medicine

基　　金：广西高校中青年教师科研基础能力提示项目(2018KY0333)。

摘　　要：目的分析红细胞寿命(RBCS)在肿瘤相关性贫血诊断中的特点及临床应用价值。方法选取2018年1月至2019年12月在广西科技大学第一附属医院、广西科技大学第二附属医院住院的150例肿瘤相关性贫血与肾性贫血患者(试验组),再将其分为恶性血液肿瘤贫血组(白血病贫血、多发性骨髓瘤贫血)、肾性贫血组、实体肿瘤放化疗相关性贫血组,另收集广西科技大学第二附属医院和广西科技大学第一附属医院同期行常规体检的30例无贫血健康人(对照组)。测定各组一氧化碳(CO)浓度并计算RBCS,对比其差异性。结果试验组RBCS(56.61±18.49)d短于对照组(119.34±23.71)d,差异有统计学意义(P<0.05)。恶性血液肿瘤贫血组RBCS(30.34±12.67)d,短于肾性贫血组(82.65±26.80)d及实体肿瘤放化疗相关性贫血组(53.62±16.94)d,差异均有统计学意义(P<0.05);实体肿瘤放化疗相关性贫血组RBCS短于肾性贫血组,差异有统计学意义(P<0.05)。结论RBCS对肿瘤相关性贫血的诊断具有一定的参考价值。Objective To analyze the characteristics and clinical application value of erythrocyte life span(RBCS)in the diagnosis of tumor associated anemia.Methods A total of 150 patients with tumor related anemia and renal anemia hospitalized in the First Affiliated Hospital and the Second Affiliated Hospital of Guangxi University of Science and Technology from January 2018 to December 2019 were selected as the experimental group and then re-divided into the malignant hematological tumor anemia group(leukemia anemia and multiple myeloma anemia),renal anemia group and solid tumor radiochemotherapeutic related anemia.Thirty healthy subjects without anemia undergoing the routine physical examination in these two hospitals at the same time were collected as the control group.The CO concentration was detected in each group and RBCS was calculated for comparing their differences.Results RBCS in the experimental group was(56.61±18.49)d,which was shorter than(119.34±23.71)d in the control group,and the difference was statistically significant(P<0.05).RBCS in the malignant hematological tumor anemia group was(30.34±12.67)d,which was shorter than(82.65±26.80)d in the renal anemia group and(53.62±16.94)d in the solid tumor radiochemotherapeutic related anemia group,and the difference was statistically significant(P<0.05);RBCS in the solid tumor radiochemotherapeutic anemia group was shorter than that in the renal anemia group,and the difference was statistically significant(P<0.05).Conclusion RBCS has a certain reference value for the diagnosis of tumor associated anemia.

关 键 词：红细胞寿命 肿瘤相关性贫血 诊断 特点 临床应用 

分 类 号：R730.4[医药卫生—肿瘤]