胃癌患者血清S100P、ILF3和PARP1水平与肿瘤病理特征的相关性分析  

Analysis on correlations between serum S100P,ILF3 and PARP1 levels with tumor pathological characteristics in patients with gastric cancer

作　　者：吕春燕 彭捷 龚啟斌 郑曼飞 LYU Chunyan;PENG Jie;GONG Qibin;ZHENG Manfe(Department of Clinical Laboratory,Affiliated Ningde Municipal Hospital,Ningde Normal University,Ningde,Fujian 362100,China)

机构地区：[1]宁德师范学院附属宁德市医院检验科,福建宁德362100

出　　处：《重庆医学》2022年第2期292-296,共5页Chongqing medicine

摘　　要：目的探讨胃癌患者血清S100钙结合蛋白(S100P)、白细胞介素增强结合因子3(ILF3)、聚腺苷酸二磷酸核糖聚合酶1(PARP1)水平与肿瘤病理特征的相关性。方法选取2017年10月至2019年1月该院确诊胃癌患者93例为研究组,选择同期93例胃部良性肿瘤患者为对照组。比较两组患者血清S100P、ILF3和PARP1水平,分析血清S100P、ILF3、PARP1水平与胃癌病理特征的关系,以及诊断胃癌的效能。结果研究组血清S100P水平低于对照组,ILF3和PARP1水平高于对照组,差异有统计学意义(P<0.05)。胃癌低分化患者血清S100P水平低于中高分化患者,ILF3和PARP1水平升高,差异有统计学意义(P<0.05);临床Ⅰ~Ⅱ期患者血清S100P水平高于Ⅲ~Ⅳ期患者,ILF3和PARP1水平降低,差异有统计学意义(P<0.05);淋巴结转移阳性患者血清S100P水平低于阴性患者,ILF3和PARP1水平升高,差异有统计学意义(P<0.05)。胃癌分化程度和TNM分期与血清S100P水平呈正相关(P<0.05),与ILF3和PARP1水平呈负相关(P<0.05);淋巴结转移与血清S100P水平呈负相关(P<0.05),与ILF3和PARP1水平呈正相关(P<0.05)。研究组随访1年死亡患者血清S100P水平低于存活患者,ILF3和PARP1水平升高(P<0.05)。血清S100P、ILF3、PARP1联合预测胃癌患者死亡的曲线下面积(AUC)为0.871,大于各指标单独预测的AUC(0.804、0.821和0.792)。结论血清S100P、ILF3、PARP1是胃癌诊断的重要生物标志物。Objective To investigate the correlation between serum S100 calcium binding protein(S100P),interleukin enhanced binding factor 3(ILF3)and poly(ADP-ribose)polymerase 1(PARP1)levels with the tumor pathological characteristics in the patients with gastric cancer patients.Methods Ninety-three patients with definitely diagnosed gastric cancer in this hospital from October 2017 to January 2019 were selected as the research group,contemporaneous 93 patients with benign gastric tumor were selected as the control group.The levels of serum S100P,ILF3 and PARP1 were compared between the two groups.Their relation with the pathological characteristics of gastric cancer and the efficiency for diagnosing gastric cancer were analyzed.Results The level of serum S100P in the research group was lower than that in the control group,the levels of ILF3 and PARP1 were higher than those in the control group,and the differences were statistically significant(P<0.05).The serum S100P level in the patients with lower differentiation gastric cancer was lower than that in the patients with middle and higher differentiation,the ILF3 and PARP1 levels were increased,and the differences were statistically significant(P<0.05);the level of S100P in patients with clinical stageⅠ-Ⅱwas higher than those in the patients with stageⅢ-Ⅳ,the ILF3 and PARP1 levels were decreased,and the differences were statistically significant(P<0.05);the level of S100P in the patients with lymph node metastasis positive was lower than that in the patients with negative,levels of ILF3 and PARP1 were increased,and the differences were statistically significant(P<0.05).The differentiation degree and TNM stage of gastric cancer were positively correlated with serum S100P level(P<0.05),negatively correlated with the ILF3 and PARP1 levels(P<0.05);the lymph node metastasis was negatively correlated with serum S100P level,and positively correlated with the ILF3 and PARP1 levels(P<0.05).The serum S100P level during 1-year follow-up in the death patients of the research gr

关 键 词：胃癌 S100钙结合蛋白 白细胞介素增强结合因子3 聚腺苷酸二磷酸核糖聚合酶1 病理特征 

分 类 号：R735.2[医药卫生—肿瘤]