3-溴丙酮酸与纳米材料结合应用于肿瘤治疗的研究进展  

Study advances on application of combination of 3-bromopyruvate and nanomaterials in tumor treatment

作　　者：何依蔓(综述) 张亮[2] 王冬(审校)[1] HE Yiman;ZHANG Liang;WANG Dong(Department of Ultrasound,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of Ultrasound,Second Affiliated Hospital of Chongqing Medical University,Chongqing,400010,China)

机构地区：[1]重庆医科大学附属第一医院超声科,400016 [2]重庆医科大学附属第二医院超声科,400010

出　　处：《重庆医学》2022年第2期331-335,共5页Chongqing medicine

基　　金：国家自然科学基金面上项目(81771845);重庆市自然科学基金重点项目(cstc2019jcyj-zdxmX0019)。

摘　　要：能量代谢异常是肿瘤的典型特征之一,大多数肿瘤高度依赖有氧糖酵解来快速获取能量,这种现象称为“Warburg”效应。与传统放化疗策略相比,抑制有氧糖酵解能够更加高效地限制肿瘤能量的产生,从而抑制肿瘤细胞增殖。已有大量实验证明,小分子烷基化试剂3-溴丙酮酸作为有氧糖酵解的抑制剂,可以有效抑制恶性肿瘤的增殖,同时不损伤正常组织。游离的3-溴丙酮酸在临床上的应用仍存在问题与争议。而将3-溴丙酮酸和新型纳米材料结合,能改善3-溴丙酮酸的稳定性、靶向性及生物安全性等一系列问题。Abnormal energy metabolism is one of the typical characteristics of tumors.Most tumors are highly dependent on aerobic glycolysis to obtain energy quickly.This phenomenon is called the"Warburg"effect.Compared with the traditional radio-chemotherapeutic strategies,inhibiting aerobic glycolysis can more efficiently limit the production of tumor energy,thereby inhibiting the tumor cell proliferation.A large number of experiments have proved that the small molecule alkylating agent 3-bromopyruvate,as an inhibitor of aerobic glycolysis,can effectively inhibit the proliferation of malignant tumors without damaging the normal tissues.However,there are still problems and controversies in the clinical application of free 3-bromopyruvate.The combination of 3-bromopyruvate and new nanomaterials can improve a series of problems of 3-bromopyruvate such as the stability,targeting and biological safety.

关 键 词：3-溴丙酮酸 纳米材料 肿瘤代谢 肿瘤治疗 

分 类 号：R73-36[医药卫生—肿瘤]