Pyk2在消化道肿瘤中调控作用的研究进展  

Research progress of Pyk2′s regulatory role in digestive tumors

作　　者：程鹏 张昱[2] 唐慧(综述)[2] 郭强(审校)[2] CHENG Peng;ZHANG Yu;TANG Hui;GUO Qiang(Medical College of Kunming University of Science and Technology,Kunming,Yunnan 650031,China;Department of Gastroenterology,Yunnan Provincial First People′s Hospital,Kunming,Yunnan 650500,China)

机构地区：[1]昆明理工大学医学院,昆明650031 [2]云南省第一人民医院消化内科,昆明650500

出　　处：《重庆医学》2022年第2期336-340,347,共6页Chongqing medicine

基　　金：国家自然科学基金项目(81860522)。

摘　　要：富含脯氨酸的酪氨酸激酶2(Pyk2)以组织依赖的方式在多种组织细胞中表达。作为一种非受体型蛋白激酶参与多条癌症信号通路,Pyk2对多数消化道肿瘤的增殖、迁移及侵袭等起着重要的调控作用,与肿瘤的预后密切相关。然而,也有少数研究表明,Pyk2在某些消化道肿瘤中具有抑癌作用。因此,需要对Pyk2的矛盾表型有更全面地了解。该文综述了Pyk2的结构功能、在消化道肿瘤中的调控及其抑制剂在相应肿瘤的应用。Proline-rich tyrsosine kinase 2(Pyk2)is expressed in a variety of tissue cells with a tissue-dependent manner.As a non-receptor protein kinase,Pyk2 involves in many tumor signaling pathways,plays an important regulating role in the proliferation,migration and invasion of most gastrointestinal tumors and is closely related to the prognosis of tumors.However,a few studies have shown that Pyk2 has the anti-tumor effect in some gastrointestinal tumors.Therefore,it is necessary to have a more comprehensive understanding for the paradoxical phenotype of Pyk2.This paper reviews the structure and function of Pyk2,its regulation in gastrointestinal tumors and the application of its inhibitors in corresponding tumors.

关 键 词：富含脯氨酸的酪氨酸激酶2 黏着斑激酶 消化道肿瘤 

分 类 号：R730.22[医药卫生—肿瘤]