口腔正畸联合药物干预在牙周炎患者中的临床效果及对炎性因子的影响研究  

Study on the clinical effect of orthodontics combined with drug intervention in patients with periodontal inflammation and its influence on inflammatory factors

作　　者：刘世颖 李霞[3] 范崇巍 刘筱琳 LIU Shi-ying;LI Xia;FAN Chong-wei(Department of Orthodontics,Dalian Stomatological Hospital,Dalian 116021,China)

机构地区：[1]大连市口腔医院正畸科,116021 [2]大连市口腔医院牙周科,116021 [3]大连医科大学附属第一医院正畸科,116011

出　　处：《中国现代药物应用》2022年第1期67-69,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨口腔正畸联合药物干预对牙周炎患者的临床效果及对炎性因子的影响。方法 106例牙周炎患者,依据抽签法分为常规组与观察组,各53例。常规组予以替硝唑治疗,观察组在常规组基础上给予口腔正畸治疗。对比两组治疗前后炎性因子水平及治疗效果。结果治疗后,观察组白细胞介素-6(IL-6)为(2.14±0.07)pg/ml、肿瘤坏死因子-α(TNF-α)为(60.05±3.28)pg/ml,均低于常规组的(5.44±0.25)pg/ml、TNF-α(69.24±4.67)pg/ml,差异均有统计学意义(P<0.05)。观察组治疗总有效率为90.57%,明显高于常规组的69.81%,差异有统计学意义(P<0.05)。结论口腔正畸联合药物干预能够有效缓解牙周炎患者的临床症状,同时能够有效降低患者的炎性细胞因子水平,值得临床推广应用。Objective To discuss the clinical effect of orthodontics combined with drug intervention in patients with periodontal inflammation and its influence on inflammatory factors. Methods A total of 106 patients with periodontal inflammation were divided into conventional group and observation group according to the lottery method, with 53 cases in each group. The conventional group received tinidazole treatment,and the observation group received orthodontic treatment on the basis of the conventional group. The levels of inflammatory factors before and after treatment and the therapeutic effect were compared between the two groups. Results After treatment, the interleukin-6(IL-6)(2.14±0.07) pg/ml, and tumor necrosis factor-α(TNF-α)(60.05±3.28) pg/ml of the observation group were lower than(5.44±0.25) pg/ml and(69.24±4.67) pg/ml of the conventional group, and the difference was statistically significant(P<0.05). The total effective rate of treatment 90.56% in the observation group was significantly higher than 69.81% in the conventional group,and the difference was statistically significant(P<0.05). Conclusion Orthodontic combined with drug intervention can effectively alleviate the clinical symptoms of periodontal inflammation patients, and can effectively reduce the level of inflammatory cytokines in patients, which is worthy of clinical promotion and application.

关 键 词：口腔正畸 药物干预 牙周炎 临床效果 炎性因子 

分 类 号：R781.42[医药卫生—口腔医学]