m6A修饰在前列腺癌中的研究进展  

Research progress of N6-methyladenosine modification in prostate cancer

作　　者：袁野 黄浩 谭伟[1] 胡自力[1] Yuan Ye;Huang Hao;Tan Wei;Hu Zili(Department of Urology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院泌尿外科,400010

出　　处：《国际外科学杂志》2021年第12期852-857,共6页International Journal of Surgery

摘　　要：前列腺癌是全球男性因癌症死亡的主要原因之一,高危型前列腺癌及去势抵抗性前列腺癌的治疗仍然具有挑战性。表观遗传学修饰在肿瘤领域逐步得到重视,其中N6-腺苷酸甲基化(m6A)作为真核细胞中常见的RNA修饰,是由m6A甲基转移酶、去甲基酶、识别蛋白共同参与调节的动态可逆过程,可通过调控基因表达调节机体生理过程及肿瘤的进展。m6A修饰在前列腺癌的发生、发展中发挥重要作用,有望在诊断、治疗及预后评估中成为新的靶点。本文围绕m6A修饰及其在前列腺癌中表达、作用和机制,以及临床应用的新思路作一综述。Prostate cancer is one of the leading cause of male cancer-related death worldwide,and the treatment of high-risk prostate cancer and castration resistant prostate cancer remains a significant challenge.Epigenetic modification has been paid more attention in the field of tumor,as a common RNA modification in eukaryotic cells,N6-methyladenosine(m6A)methylation is a dynamic and reversible process regulated by m6A methyltransferase,demethylase and recognition protein,which can regulate the physiological process and tumor progression by regulating gene expression.m6A modification plays an important role in the occurrence and development of prostate cancer and is expected to become a new target in diagnosis,treatment and prognosis.This article reviews the m6A modification and its expression,function and mechanism in prostate cancer,as well as new ideas for clinical application.

关 键 词：甲基化 6-甲基腺嘌呤 前列腺肿瘤 综述 

分 类 号：R737.25[医药卫生—肿瘤]