超顺磁性氧化铁纳米粒子在乳腺癌前哨淋巴结活检中的应用现状  

Application status of superparamagnetic iron oxide in sentinel lymph node biopsy for breast cancer

作　　者：钱治丹 章佳新 Qian Zhidan;Zhang Jiaxin(Dalian Medical University,Dalian 116044,China;Department of Thyroid and Breast Surgery,Northern Jiangsu People′s Hospital,Yangzhou 225001,China)

机构地区：[1]大连医科大学,116044 [2]苏北人民医院甲乳外科,扬州225001

出　　处：《国际外科学杂志》2021年第12期857-860,共4页International Journal of Surgery

摘　　要：腋窝淋巴结状况是乳腺癌最重要的预后指标,因此准确评估腋窝淋巴结转移的状况始终是乳腺癌研究的热点问题。现如今,前哨淋巴结活检已成为腋窝淋巴结临床阴性早期乳腺癌患者的首选手术方式。示踪剂的选择又是进行乳腺癌前哨淋巴结活检和淋巴引流区域研究的关键环节,传统示踪剂(蓝色染料、核素和荧光示踪剂等)过敏、定位特异性差、对人体放射性等问题,限制了其在临床的推广应用。然而,超顺磁性氧化铁纳米粒子(SPION)有效地改善了这些缺点,具有其他示踪剂无法替代的优势,可成为乳腺癌前哨淋巴结活检的理想示踪剂,具有良好的应用前景。本文就目前SPION在乳腺癌前哨淋巴结活检中的应用情况及该示踪剂的优缺点作一综述。The axillary lymph node status is the most important prognostic index of breast cancer,so the accurate assessment of axillary lymph node metastasis has always been a hot topic in breast cancer research.Today,sentinel lymph node biopsy(SLNB)has become the preferred surgical procedure for axillary lymph node negative early breast cancer.The selection of tracers is also a key link in the study of SLNB and lymphatic drainage area of breast cancer.Traditional tracers(blue dye,nuclide and fluorescent tracers,etc.)have many problems,such as allergy,poor localization specificity and radioactivity to human body,which limit their promotion and application in clinic.However,superparamagnetic iron oxide nanoparticle(SPION)can effectively improve these shortcomings and has the advantages that other tracers cannot replace.It can be an ideal tracer for SLNB of breast cancer and has a good application prospect.This article mainly describes the current application of SPION in SLNB of breast cancer,and outlines the advantages and disadvantages of this tracer.

关 键 词：乳腺肿瘤 前哨淋巴结活组织检查 超顺磁性氧化铁 

分 类 号：R737.9[医药卫生—肿瘤]