RNA m^(5)C甲基化修饰在肿瘤中的研究进展  

Research progress on post-translational RNA 5-methylcytosine methylation in tumors

作　　者：张安琪 安萌 姜博 唐文强[1] 潘丽[1] 付波 Anqi Zhang;Meng An;Bo Jiang;Wenqiang Tang;Li Pan;Bo Fu(Department of Central Laboratory,Liaocheng People’s Hospital Affiliated to Shandong First Medical University,Liaocheng 252000,China;Department of Clinical Laboratory,Liaocheng People’s Hospital,Liaocheng People’s Hospital Affiliated to Shandong First Medical University,Liaocheng 252000,China)

机构地区：[1]山东第一医科大学附属聊城医院,聊城市人民医院中心实验室,山东省聊城市252000 [2]山东第一医科大学附属聊城医院,聊城市人民医院检验科,山东省聊城市252000

出　　处：《中国肿瘤临床》2021年第24期1277-1281,共5页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金项目(编号:81702884)资助。

摘　　要：5-甲基胞嘧啶(5-methylcytosine,m^(5)C)是RNA中重要的甲基化修饰之一,也是近年来的研究热点。随着甲基化测序技术的发展,在编码RNA及非编码RNA中均证实存在大量的m5C甲基化修饰。RNA m^(5)C甲基化修饰受m^(5)C甲基转移酶、去甲基化酶及m5C甲基化结合蛋白的调控。m^(5)C甲基化修饰调节RNA的稳定性、转运、翻译和压力应激等,并参与调节肿瘤的发生发展、侵袭转移、肿瘤耐药等进程。本文对RNA m^(5)C甲基化修饰的调控机制、功能以及在肿瘤中的研究进展进行综述,以期为肿瘤诊治研究提供新思路。5-methylcytosine(m^(5)C)is an important post-translationally modified base in RNA formed by cytosine methylation.As the development of methylation sequencing techniques,extensive m^(5)C modifications have been found in both coding and non-coding RNA.Incorporation of m^(5)C into RNA is regulated by methyltransferases,demethylases,and m^(5)C-binding proteins.m^(5)C incorporation regulates RNA stability,transport,translation,and pressure stress.Recent studies have revealed that m^(5)C incorporation into RNA is involved in the regulation of tumor pathogenesis,development,invasion,metastasis,and resistance.This article reviews m^(5)C-mediated regulatory mechanisms and functions,and research progress on m^(5)C-modified RNA functions in tumors,thus providing novel insights for developing innovative tumor diagnostic and therapeutic strategies.

关 键 词：m^(5)C甲基化修饰 编码RNA 非编码RNA 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]